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This study aims to investigate whether genetic variations in key ITC\u2010metabolizing\/functioning genes modify the associations between dietary ITC exposure and NMIBC prognosis outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In the Bladder Cancer Epidemiology, Wellness, and Lifestyle Study (Be\u2010Well Study), a prospective cohort of 1472 incident NMIBC patients, dietary ITC exposure is assessed by self\u2010reported CV intake and measured in plasma ITC\u2010albumin adducts. Using Cox proportional hazards regression models, stratified by single nucleotide polymorphisms (SNPs) in nine key ITC\u2010metabolizing\/functioning genes, it is calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for recurrence and progression. The rs15561 in N\u2010acetyltransferase 1 (<jats:italic>NAT1)<\/jats:italic> is alter the association between CV intake and progression risk. Multiple SNPs in nuclear factor E2\u2010related factor 2 (<jats:italic>NRF2<\/jats:italic>) and nuclear factor kappa B (<jats:italic>NF\u03baB)<\/jats:italic> are modify the associations between plasma ITC\u2010albumin adduct level and progression risk (<jats:italic>p<\/jats:italic><jats:sub>int<\/jats:sub> &lt; 0.05). No significant association is observed with recurrence risk. Overall, &gt;80% study participants are present with at least one protective genotype per gene, showing an average 65% reduction in progression risk with high dietary ITC exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite that genetic variations in ITC\u2010metabolizing\/functioning genes may modify the effect of dietary ITCs on NMIBC prognosis, dietary recommendation of CV consumption may help improve NMIBC survivorship.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400087","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T11:54:14Z","timestamp":1712404454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modifying Effects of Genetic Variations on the Association Between Dietary Isothiocyanate Exposure and Non\u2010muscle Invasive Bladder Cancer Prognosis in the Be\u2010Well Study"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-6995","authenticated-orcid":false,"given":"Zinian","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention and Control Roswell Park Comprehensive Cancer Center  Buffalo NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn L.","family":"Kwan","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reina","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Kaiser Permanente Southern California  Pasadena CA USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. 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