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Alcohol causes damages to various organs, including intestine and liver, primarily involved in its absorption and metabolism. However, alcohol\u2010related organ damage risk varies significantly among individuals, even when they report consuming comparable dosages of alcohol. Factor(s) that may modulate the risk of organ injuries from alcohol consumption could be responsible for inter\u2010individual variations in susceptibility to alcohol\u2010related organ damages. Accumulating evidence suggests disruptions in circadian rhythm can exacerbate alcohol\u2010related organ damages. Here we investigated the interplay between alcohol, circadian rhythm, and key tissue cellular processes at baseline, after a regular and a shift in the light\/dark cycle (LCD) in mice. Central\/peripheral clock expression of core clock genes (CoClGs) was analyzed. We also studied circadian homeostasis of tissue cellular processes that are involved in damages from alcohol. These experiments reveal that alcohol affects the expression of CoClGs causing a central\u2010peripheral dyssynchrony, amplified by shift in LCD. The observed circadian clock dyssynchrony was linked to circadian disorganization of key processes involved in the alcohol\u2010related damages, particularly when alcohol was combined with LCD. These results offer insights into the mechanisms by which alcohol interacts with circadian rhythm disruption to promote organ injury.<\/jats:p>","DOI":"10.1002\/mnfr.202400234","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T05:00:35Z","timestamp":1723266035000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Alcohol on Clock Synchrony and Tissue Circadian Homeostasis in Mice"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0807-3893","authenticated-orcid":false,"given":"Luca S.","family":"Santovito","sequence":"first","affiliation":[{"name":"Rush Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliha","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Rush Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Sharma","sequence":"additional","affiliation":[{"name":"Rush Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Rush Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago IL 60612 USA"},{"name":"Departments of Medicine, Anatomy and Cell Biology Rush University Medical Center  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin M.","family":"Voigt","sequence":"additional","affiliation":[{"name":"Rush Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago IL 60612 USA"},{"name":"Departments of Medicine, Anatomy and Cell Biology Rush University Medical Center  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Keshavarzian","sequence":"additional","affiliation":[{"name":"Rush Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago IL 60612 USA"},{"name":"Departments of Medicine, Anatomy and Cell Biology Rush University Medical Center  Chicago IL 60612 USA"},{"name":"Department of Physiology Rush University Medical Center  Chicago IL 60612 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faraz","family":"Bishehsari","sequence":"additional","affiliation":[{"name":"Rush Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago IL 60612 USA"},{"name":"MD Anderson Cancer Center\u2010UTHealth Houston Graduate School of Biomedical Sciences  Houston TX 77030 USA"},{"name":"Division of Gastroenterology, Hepatology &amp; Nutrition, Department of Internal Medicine, Gastroenterology Research Center University of Texas  Houston TX 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"997","volume":"294","author":"Banan A.","year":"2000","journal-title":"J. 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