{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:06:02Z","timestamp":1766138762387,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012633","name":"INNOPOLIS Foundation","doi-asserted-by":"publisher","award":["2021\u2010JB\u2010RD\u20100097"],"award-info":[{"award-number":["2021\u2010JB\u2010RD\u20100097"]}],"id":[{"id":"10.13039\/501100012633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003712","name":"Korea Food Research Institute","doi-asserted-by":"publisher","award":["E0210203"],"award-info":[{"award-number":["E0210203"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Long\u2010term consumption of excessive dietary advanced glycation end\u2010products such as <jats:italic>N<\/jats:italic><jats:sup>\u03b5<\/jats:sup>\u2010carboxymethyl\u2010lysine (CML), which are produced by the Maillard reaction during food thermal processing, leads to nonalcoholic fatty liver disease (NAFLD) along with high fat consumption. The study previously finds that administration of <jats:italic>Lactococcus lactis<\/jats:italic> KF140 (LL\u2010KF140) detoxifies CML by decreasing CML absorption both in a rat model and clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The present study evaluates the ameliorative effect of LL\u2010KF140 on NAFLD and fatty liver\u2010related biomarkers in a mouse model induced by CML and high fat. LL\u2010KF140 is orally administered to mice at a concentration of 1 \u00d7 10<jats:sup>7<\/jats:sup> or 1 \u00d7 10<jats:sup>8<\/jats:sup> colony\u2010forming unit (CFU) per mouse for 8 weeks. LL\u2010KF140 administration ameliorates the NAFLD\u2010related symptoms by reducing body weight and fat mass gain along with levels of serum aspartate transaminase, alanine transferase, and lipids as well as glucose intolerance and insulin resistance in CML\u2010treated mice. In addition, histological analysis including staining and western blotting shows that LL\u2010KF140 suppresses the lipogenesis pathway and CML absorption, thereby suppressing CML\u2010induced NAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that LL\u2010KF140 attenuates dietary CML\u2010induced NAFLD by suppressing the de novo lipogenesis pathway, and it may be used as a probiotic strain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400260","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T08:55:35Z","timestamp":1720083335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Lactococcus lactis<\/i> KF140 Ameliorates Nonalcoholic Fatty Liver Disease Induced by <i>N<sup>\u03b5<\/sup><\/i>\u2010Carboxymethyl\u2010Lysine and High\u2010Fat Diet"],"prefix":"10.1002","volume":"68","author":[{"given":"Hye\u2010Bin","family":"Lee","sequence":"first","affiliation":[{"name":"Food Functionality Research Division Korea Food Research Institute  Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miri","family":"Park","sequence":"additional","affiliation":[{"name":"Food Functionality Research Division Korea Food Research Institute  Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So\u2010Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Food Functionality Research Division Korea Food Research Institute  Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3329-2279","authenticated-orcid":false,"given":"Sang Keun","family":"Ha","sequence":"additional","affiliation":[{"name":"Food Functionality Research Division Korea Food Research Institute  Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoonsook","family":"Kim","sequence":"additional","affiliation":[{"name":"Food Functionality Research Division Korea Food Research Institute  Jeollabuk\u2010do 55365 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Korea University  Seoul 02841 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-9059","authenticated-orcid":false,"given":"Ho\u2010Young","family":"Park","sequence":"additional","affiliation":[{"name":"Food Functionality Research Division Korea Food Research Institute  Jeollabuk\u2010do 55365 Republic of Korea"},{"name":"Department of Food Biotechnology Korea National University of Science and Technology  Daejeon 34113 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415791"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080835"},{"key":"e_1_2_9_5_1","volume":"5","author":"Abate G.","year":"2015","journal-title":"J. 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