{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:22:50Z","timestamp":1789669370112,"version":"4.0.1"},"reference-count":62,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373555"],"award-info":[{"award-number":["82373555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81861138007"],"award-info":[{"award-number":["81861138007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017\u201005840"],"award-info":[{"award-number":["2017\u201005840"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>This study aims to identify the gut enterotypes that explain differential responses to intervention with whole grain rye by proposing an \u201centerotype \u2010 metabolic\u201d model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A 12\u2010week randomized controlled trial is conducted in Chinese adults, with 79 subjects consuming whole grain products with fermented rye bran (FRB) and 77 consuming refined wheat products in this exploratory post\u2010hoc analysis. Responders or non\u2010responders are identified according to whether blood glucose decreased by more than 10% after rye intervention. Compared to non\u2010responders, responders in FRB have higher baseline <jats:italic>Bacteroides<\/jats:italic> (<jats:italic>p<\/jats:italic> &lt; 0.001), associated with reduced blood glucose (<jats:italic>p<\/jats:italic> &lt; 0.001), increased <jats:italic>Faecalibacterium<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.020) and <jats:italic>Erysipelotrichaceae_UCG.003<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.022), as well as deceased 7\u03b2\u2010hydroxysteroid dehydrogenase (<jats:italic>p<\/jats:italic> = 0.033) after intervention. The differentiated gut microbiota and metabolites between responders and non\u2010responders after intervention are enriched in aminoacyl\u2010tRNA biosynthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The work confirms the previously suggested importance of microbial enterotypes in differential responses to whole grain interventions and supports taking enterotypes into consideration for improved efficacy of whole grain intervention for preventing type 2 diabetes. Altered short\u2010chain fatty acids and bile acid metabolism might be a potential mediator for the beneficial effects of whole grain rye on glucose metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400274","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T05:54:47Z","timestamp":1722578087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Personalized Microbial Fingerprint Associated with Differential Glycemic Effects of a Whole Grain Rye Intervention on Chinese Adults"],"prefix":"10.1002","volume":"68","author":[{"given":"Wenyun","family":"Li","sequence":"first","affiliation":[{"name":"School of Public Health Fudan University\/Key Laboratory of Public Health Safety Ministry of Education  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiru","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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