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Each group receives one of the following formulations in drinking water: lecithin nanovesicles, nanovesicles containing either lecithin with EA or TPA (86:14 w\/w), or water (control) for 28 days with a regular fat diet (18% calories from fat). Total RNA is extracted, and paired\u2010end sequencing is performed. TPA intake alters the expression of 351 genes compared to EA intake, including 11 downregulated and 340 upregulated genes (fold change [FC] &gt;1.5, <jats:italic>p<\/jats:italic> &lt; 0.05). TPA compares to EA upregulated: Slc5a8, Lcn2, Csf3, Scube1, Mapk13, Bdkrb2, Ctla2a, Slc2a1, Oas3, Cx3cl1, Oas2, Nlrp6, Pycard, Cyba, Ddr1, and Prkab1 and downregulated Fas gene. These genes are related to the NOD\u2010like receptor, lipid and atherosclerosis, IL\u201017 signaling, TNF, nonalcoholic fatty liver disease, cytokine\u2013cytokine receptor interaction, adipocytokine, glucagon, insulin resistance, and inflammatory mediator regulation of TRP channels signaling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TPA intake has a distinct impact on the regulation of inflammation and diabetes\u2010related pathways in adipose tissue compared to EA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400290","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T19:26:49Z","timestamp":1728847609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ruminant <i>Trans<\/i> Fatty Acid Intake Modulates Inflammation Pathways in the Adipose Tissue Transcriptome of C57BL\/6 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