{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:42Z","timestamp":1753869762951,"version":"3.41.2"},"reference-count":54,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The purpose of this study was to provide clear evidence that reliably quantifies the association of Asymmetric dimethylarginine (ADMA) levels with the risk of neurovascular diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The Pubmed, Web of Science, and Embase were systematically searched to identify eligible studies published until August 2024. A total of 31 eligible studies were identified. Pooled results indicated that patients with stroke yielded a higher ADMA level than healthy controls [standardized mean difference (SMD) = 1.02, 95% CI = 0.92\u20131.12, P = 0.001]. Subgroup analyses showed that geographical location, sample type, number of events and the proportion of male participants were statistically significant sources of heterogeneity. Similarly, a significant association with a pooled risk ratio (RR) of 1.60 (95% CI = 1.60\u20131.91) was shown between ADMA exposure and the risk of stroke from seven cohort studies. There was a statistically significant difference between ADMA level and small vessel disease (SVD) (SMD = 0.33, 95% CI = 0.07\u20130.58, <jats:italic>p<\/jats:italic> = 0.001). In addition, migraine patients tend to have elevated ADMA levels compared to healthy controls (SMD = 0.39, 95% CI = 0.11\u20130.67, P = 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that ADMA levels have significant effects in patients with stroke, SVD, and migraine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400329","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T06:29:34Z","timestamp":1731047374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Levels of Asymmetric Dimethylar Ginine and Risk of Neurovascular Diseases: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6698-2733","authenticated-orcid":false,"given":"Qinqin","family":"Dai","sequence":"first","affiliation":[{"name":"School of Nursing and Health\uff0cZhengzhou University Zhengzhou Henan Province 450001 China"},{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Nursing and Health\uff0cZhengzhou University Zhengzhou Henan Province 450001 China"},{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanli","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Nursing and Health\uff0cZhengzhou University Zhengzhou Henan Province 450001 China"},{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Nursing and Health\uff0cZhengzhou University Zhengzhou Henan Province 450001 China"},{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qilan","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Nursing and Health\uff0cZhengzhou University Zhengzhou Henan Province 450001 China"},{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aixia","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuming","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6642-1214","authenticated-orcid":false,"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Nursing and Health\uff0cZhengzhou University Zhengzhou Henan Province 450001 China"},{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province 450052 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.03.007"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15440-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.048"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2019.06.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.08.015"},{"key":"e_1_2_10_6_1","first-page":"809","volume":"31","author":"Siegerink B.","year":"2010","journal-title":"Eur. Heart J."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416651454"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1183586"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-48382-5_15"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0385"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131215983"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13237"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.18.1842"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160612230"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.06.033"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.8144"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.22582"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.12.021"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001833"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.557116"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930221144911"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50778-w"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2008.346"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.12.030"},{"key":"e_1_2_10_25_1","first-page":"82","volume":"18","author":"Sert Oksuz F.","year":"2018","journal-title":"Pain Pract."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0560-2"},{"key":"e_1_2_10_27_1","first-page":"28","volume":"17","author":"Yadav H. N.","year":"2023","journal-title":"J. Clin. Diagnost. Res."},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01964.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416651454"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414564888"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030730"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2836"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487312445001"},{"key":"e_1_2_10_34_1","first-page":"14","volume":"10","author":"B\u00f6ger R. H.","year":"2005","journal-title":"Altern. Med. Rev."},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr304"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/2047487315586094"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104951"},{"key":"e_1_2_10_38_1","first-page":"595","volume":"29","author":"Zhang L.","year":"2013","journal-title":"Chinese J. Clin. Pharmacol."},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.09.026"},{"key":"e_1_2_10_40_1","volume":"9","author":"Chen S.","year":"2012","journal-title":"J. Neuroinflam."},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.103549"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.52547\/rbmb.10.2.302"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.04.031"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248408326488"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0323-7"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1211"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-2970-1"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18136703"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2013.0099"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1429"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-021-00351-1"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202400329","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T12:13:03Z","timestamp":1732882383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202400329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":54,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/mnfr.202400329"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202400329","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"type":"print","value":"1613-4125"},{"type":"electronic","value":"1613-4133"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400329"}}