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However, effects of lipid solid versus liquid state specifically have not been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This exploratory randomized crossover study tests the impact of lipid crystallinity on plasma levels of endotoxin transporters (lipopolysaccharide [LPS] binding protein [LBP] and soluble cluster of differentiation 14 [sCD14]) and select proinflammatory and atherogenic markers (tumor necrosis factor\u2010alpha [TNF\u2010\u03b1], C\u2010reactive protein [CRP], interleukin\u20101\u2010beta [IL\u20101\u03b2], interferon\u2010gamma [IFN\u2010\u03b3], interleukin\u20106 [IL\u20106], soluble intercellular adhesion molecule [sICAM], soluble vascular cell adhesion molecule [sVCAM], monocyte chemoattractant protein\u20101 [MCP\u20101\/CCL2], plasminogen activator inhibitor\u20101 [PAI\u20101], and fibrinogen). Fasted healthy men (<jats:italic>n<\/jats:italic> = 14, 28 \u00b1 5.5 years, 24.1 \u00b1 2.6\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup>) consumed two 50\u00a0g palm stearin oil\u2010in\u2010water emulsions tempered to contain either liquid or crystalline lipid droplets at 37\u00a0\u00b0C on separate occasions with blood sampling at 0, 2\u2010, 4\u2010, and 6\u2010h post\u2010meal. Timepoint data, area under the curve, and peak concentration values are compared. Overall, no treatment effects are seen (<jats:italic>p<\/jats:italic> &gt; 0.05). There are significant effects of time, with values decreasing from baseline, for TNF\u2010\u03b1, MCP\u20101\/CCL2, PAI\u20101, and fibrinogen (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Responder analysis pointed to differential treatment effects associated with some participant baseline characteristics but, overall, palm\u2010stearin emulsion droplet crystallinity does not acutely affect plasma endotoxin transporters nor select inflammatory and atherogenic markers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400365","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T17:44:33Z","timestamp":1728582273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Emulsion Lipid Droplet Crystallinity on Postprandial Endotoxin Transporters and Atherogenic And Inflammatory Profiles in Healthy Men \u2013 A Randomized Double\u2010Blind Crossover Acute Meal Study"],"prefix":"10.1002","volume":"68","author":[{"given":"Erik S.","family":"Dassoff","sequence":"first","affiliation":[{"name":"Human Health and Nutritional Sciences College of Biological Sciences University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar","family":"Hamad","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences College of Biological Sciences University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaina","family":"Campagna","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences College of Biological Sciences University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surangi H.","family":"Thilakarathna","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences College of Biological Sciences University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Caroline","family":"Michalski","sequence":"additional","affiliation":[{"name":"INRAE CarMeN Laboratory Inserm Univ\u2010Lyon Universit\u00e9 Claude Bernard Lyon Centre de Recherche en Nutrition Humain Rh\u00f4ne\u2010Alpes  Pierre B\u00e9nite France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6178-1961","authenticated-orcid":false,"given":"Amanda J.","family":"Wright","sequence":"additional","affiliation":[{"name":"Human Health and Nutritional Sciences College of Biological Sciences University of Guelph  Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00039.2017"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00197.2013"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00198.2018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-10-30"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.201681"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S229691"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmac071"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14040831"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.963471"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.07.018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4137"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.12585"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510005581"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2021.101129"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2021.05.021"},{"key":"e_1_2_9_16_1","first-page":"451","volume":"8","author":"Kim D.","year":"2013","journal-title":"Int. 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