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Cocoa treatment continues during the DSS period. Cocoa and\/or cocoa fractions exacerbate DSS\u2010induced weight loss and fail to mitigate DSS\u2010induced colon shortening but do improve splenomegaly. Cocoa\/cocoa fraction treatment fails to mitigate DSS\u2010induced mRNA and protein markers of inflammation. Principal component analysis shows overlap between cocoa or cocoa fraction\u2010treated mice and DSS\u2010induced controls, but separation from mice not treated with DSS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest cocoa and cocoa polyphenols may not be useful in mitigating acute colonic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400431","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T03:58:47Z","timestamp":1720151927000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cocoa and Polyphenol\u2010Rich Cocoa Fractions Fail to Improve Acute Colonic Inflammation in Dextran Sulfate Sodium\u2010Treated Mice"],"prefix":"10.1002","volume":"68","author":[{"given":"Daphne K.","family":"Weikart","sequence":"first","affiliation":[{"name":"Department of Food Science The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiana M.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Food Science The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Sweet","sequence":"additional","affiliation":[{"name":"Plants for Human Health Institute North Carolina State University  Kannapolis NC 28081 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley M.","family":"McAmis","sequence":"additional","affiliation":[{"name":"Plants for Human Health Institute North Carolina State University  Kannapolis NC 28081 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Hopfer","sequence":"additional","affiliation":[{"name":"Department of Food Science The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5497-663X","authenticated-orcid":false,"given":"Andrew P.","family":"Neilson","sequence":"additional","affiliation":[{"name":"Plants for Human Health Institute North Carolina State University  Kannapolis NC 28081 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-7398","authenticated-orcid":false,"given":"Joshua D.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Food Science The Pennsylvania State University  University Park PA 16802 USA"},{"name":"The Center for Molecular Toxicology and Carcinogenesis The Pennsylvania State University  University Park PA 16802 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30333-4"},{"key":"e_1_2_9_2_1","first-page":"367","volume":"9","author":"Ananthakrishnan A. 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