{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:57:07Z","timestamp":1791489427628,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>\n<jats:italic>Cordyceps cicadae<\/jats:italic> polysaccharides have received attention due to their potential in treating hyperglycemia and enhancing renal function. The beneficial effect of the purified <jats:italic>C. cicadae<\/jats:italic> polysaccharides fraction (CCP\u20101) on the reproductive impairments and spermatogenesis dysfunction of immunocompromised mice is unavailable and is studied herein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The study establishes a GC\u20101 spg cell apoptosis model induced by TNF\u2010\u03b1+SM\u2010164 (TS) and male mouse reproductive injury model induced by cyclophosphamide (CTX), and then intervened by CCP\u20101. CCP\u20101 improves the viability of GC\u20101 spg cell and inhibits cells apoptosis induced by TS in vitro. CCP\u20101 enhances sperm quality and spermatogenesis function, as well as ameliorating the histological lesions in the hypothalamus, testicular, and kidney. CCP\u20101 elevates gonadotropin\u2010releasing hormone (GnRH) level that secreted by the hypothalamus, and increases the levels of follicle stimulating hormone (FSH) and luteizing hormone (LH) in the anterior pituitary stimulated by GnRH, and promotes the secretion of testosterone (T) by testis. Moreover, CCP\u20101 could protect the reproductive system by activating reproductive regulatory pathway such as SCF\/C\u2010kit pathway and inhibiting apoptotic signaling pathway such as Bax\/Caspase\u20103 pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results manifest that CCP\u20101 could serve as a natural promising reproductive system protective supplement for ameliorating CTX biotoxicity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400446","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T05:08:54Z","timestamp":1731647334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Polysaccharides from <i>Cordyceps cicadae<\/i> Ameliorate Reproductive Impairments in Male Mouse through the Hypothalamic\u2010Pituitary\u2010Testicular Axis"],"prefix":"10.1002","volume":"68","author":[{"given":"Fen","family":"Wu","sequence":"first","affiliation":[{"name":"School of life Sciences Anhui University Hefei  Hefei 230601 P. 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