{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:34:26Z","timestamp":1788298466780,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Consuming cocoa rich in flavan\u20103\u2010ols (particularly epicatechin [EC]) may reduce vascular stiffness and blood pressure (BP) and improve serum lipid profiles. Because interventional studies on pure EC exhibited inconclusive results, the role of other cocoa ingredients such as methylxanthines (MX) on vascular health was assumed. This study aimed to systematically compare the effects of flavanol\u2010rich cocoa and its major components EC and MX on vascular function and serum lipid levels. In a randomized controlled trial (RCT), 75 healthy young adults ingested capsules containing either (i) flavanol\u2010rich cocoa powder, (ii) EC, (iii) MX, (iv) EC\u00a0+\u00a0MX, or (v) placebo (<jats:italic>n\u00a0<\/jats:italic>=\u00a015 per group) daily for 4 weeks. Capsules provided equal amounts of EC and\/or MX as the cocoa capsules. Pulse wave velocity (PWV), BP, endothelin\u20101, and lipids were investigated before and after intervention. No group\u2010specific statistically significant differences in aortic PWV (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.410) or any other parameters (<jats:italic>p\u00a0<\/jats:italic>\u2265\u00a00.05) were observed between before and after the intervention. Daily intake of neither flavanol\u2010rich cocoa nor pure cocoa ingredients influenced vascular function and lipid profiles in healthy adults. Consequently, RCTs involving subjects with increased cardiometabolic risk may clarify the effects of EC and MX as cocoa components on cardiovascular health parameters.<\/jats:p><jats:p><jats:bold>Trial Registration<\/jats:bold>: URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\/search\/en\/trial\">https:\/\/drks.de\/search\/en\/trial<\/jats:ext-link>. Unique identifier: DRKS00022056<\/jats:p>","DOI":"10.1002\/mnfr.202400490","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:49:01Z","timestamp":1738648141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiometabolic Impact of Encapsulated Cocoa Powder and Pure Cocoa Ingredients Supplementation: A Comparative Placebo\u2010Controlled RCT in Adults"],"prefix":"10.1002","volume":"69","author":[{"given":"Janina","family":"Weigant","sequence":"first","affiliation":[{"name":"Faculty of Agricultural, Nutritional and Engineering Sciences, Institute of Nutritional and Food Science, Human Nutrition University of Bonn  Bonn Germany"},{"name":"Department of Nutritional and Food Sciences Niederrhein University of Applied Sciences  M\u00f6nchengladbach 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M\u00f6nchengladbach Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9877-7066","authenticated-orcid":false,"given":"Benno F.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Faculty of Agricultural, Nutritional and Engineering Sciences, Institute of Nutritional and Food Science, Food Sciences University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schmid","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical Biometry, Informatics and Epidemiology (IMBIE) University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Weinhold","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical Biometry, Informatics and Epidemiology (IMBIE) University of Bonn  Bonn 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