{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:07:26Z","timestamp":1782097646892,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>This study investigates whether vitamin E (VE) deficiency in subjects with obesity could, at least partly, be due to a defect in VE intestinal absorption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Mice follow either a high\u2010fat (HF) or a control (CTL) diet for 12 weeks. The study evaluates their VE status, the expression of genes encoding proteins involved in lipid and fat\u2010soluble vitamin intestinal absorption, and VE absorption using a \u03b3\u2010tocopherol\u2010rich emulsion. HF mice have a weight (+23.0%) and an adiposity index (AI, +157.0) superior to CTL mice (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). \u03b1\u2010Tocopherol concentrations are higher in both plasma (+45.0%) and liver (+116.9%) of HF mice compared to CTL mice (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). \u03b1\u2010Tocopherol concentration in the adipose tissue of HF mice is higher than that of CTL mice after correction by the AI (+72.4%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). No difference is found in the expression of genes coding for proteins involved in intestinal lipid metabolism in fasting mice. After force\u2010feeding, \u03b3\u2010tocopherol plasma concentration is higher in HF mice compared to CTL mice (+181.5% at 1.5\u00a0h after force\u2010feeding, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HF mice display higher status and more efficient absorption of VE than CTL mice. VE absorption is thus likely not impaired in the early stages of obesity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400509","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T12:02:28Z","timestamp":1731758548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Overweight Leads to an Increase in Vitamin E Absorption and Status in Mice"],"prefix":"10.1002","volume":"68","author":[{"given":"Katherine","family":"Alvarado\u2010Ramos","sequence":"first","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, INRAE, INSERM, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-5334","authenticated-orcid":false,"given":"\u00c1ngela","family":"Bravo\u2010N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, INRAE, INSERM, C2VN  Marseille France"},{"name":"Universidad de Valladolid  Palencia 34004 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Vairo","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, INRAE, INSERM, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Sabran","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, INRAE, INSERM, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8690-8014","authenticated-orcid":false,"given":"Jean\u2010Fran\u00e7ois","family":"Landrier","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, INRAE, INSERM, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4576-1992","authenticated-orcid":false,"given":"Emmanuelle","family":"Reboul","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille Universit\u00e9, INRAE, INSERM, C2VN  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"e_1_2_10_1_1","unstructured":"\u201cWorld Obesity Atlas 2023 \u201d available athttps:\/\/www.worldobesity.org\/resources\/resource\u2010library\/world\u2010obesity\u2010atlas\u20102023. 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