{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T16:20:35Z","timestamp":1791735635671,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["Grant No. 2020C02038"],"award-info":[{"award-number":["Grant No. 2020C02038"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>Myrica rubra<\/jats:italic>\n                    pomace polyphenols (MRPP) were used to study their hypoglycemic effects and mechanisms using Type 2 diabetes (T2D) (db\/db) mice as the model. The results showed that the oral administration of MRPP (low\u2010dose myricitrin, 50\u00a0mg\/kg BW by gavage; high\u2010dose myricitrin, 250\u00a0mg\/kg BW by gavage; and\n                    <jats:italic>Myrica rubra<\/jats:italic>\n                    pomace, 500\u00a0mg\/kg BW by gavage) for 4 weeks significantly reduced fasting blood glucose, glycated serum protein, serum insulin, and insulin resistance index in mice, as well as the dyslipidemia in mice was improved. MRPP was able to improve the structural morphology of hepatocytes and pancreatic \u03b2\u2010cells in diabetic mice. Its hypoglycemic mechanism may involve the upregulation of GLUT\u20104 and IRS\u20101 genes expression in the PI3K and AMPK signaling pathways, downregulation of GSK\u20103\u03b2, AMPK, PI3K, and AKT genes expression, and enhancement of the activity of enzymes related to glycogen synthesis and glucose metabolism. Research findings on 16S rRNA suggest that MRPP has the ability to alter the composition of the gut microbiota, impede the growth of harmful bacteria, and foster the growth of beneficial bacteria. Therefore, MRPP was capable of reshaping the specific gut microbial community and supporting its application as a novel supplement in functional foods for the treatment of T2D.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.202400523","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T03:49:33Z","timestamp":1743738573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Hypoglycemic Effects and Mechanisms of Polyphenols From\n                    <i>Myrica rubra<\/i>\n                    Pomace in Type 2 Diabetes (db\/db) Mice"],"prefix":"10.1002","volume":"69","author":[{"given":"Guoli","family":"Chang","sequence":"first","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang Provincial Key Lab for Chem &amp; Bio Processing Technology for Farm Product Zhejiang University of Science and Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang Provincial Key Lab for Chem &amp; Bio Processing Technology for Farm Product Zhejiang University of Science and Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang Provincial Key Lab for Chem &amp; Bio Processing Technology for Farm Product Zhejiang University of Science and Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Xiang","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang Provincial Key Lab for Chem &amp; Bio Processing Technology for Farm Product Zhejiang University of Science and Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-6433","authenticated-orcid":false,"given":"Chenggang","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang Provincial Key Lab for Chem &amp; Bio Processing Technology for Farm Product Zhejiang University of Science and Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang Provincial Key Lab for Chem &amp; Bio Processing Technology for Farm Product Zhejiang University of Science and Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering Zhejiang Provincial Key Lab for Chem &amp; Bio Processing Technology for Farm Product Zhejiang University of Science and Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Science Wenzhou University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Food Science Zhejiang Academy of Agricultural Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.s1.06.s43"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.10001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.53"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000230"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60613-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15663"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42531-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1174"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC07985D"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-013-0349-x"},{"key":"e_1_2_9_12_1","first-page":"1","article-title":"Fruit and fruit products as functional foods","volume":"3","author":"Shah B. 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