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We constructed polyphenols and ascorbic acid systems (PAAS) of six different floral kinds of honey by exogenous substances, to investigate their effects on alcohol metabolism in the liver. PAAS consists of 22 kinds of polyphenols (including arbutin and caffeic acid) and ascorbic acid. The results demonstrated that PAAS improved the activity of alcohol dehydrogenase (ADH) and the expression of <jats:italic>adh1<\/jats:italic>, but had no significant effect on acetaldehyde dehydrogenase (ALDH) and expression of <jats:italic>adh2<\/jats:italic>, which caused a decrease in blood ethanol concentration but no difference in acetaldehyde concentration. Correlation analysis illustrated that arbutin and trans\u20104\u2010hydroxycinnamic acid in PAAS were important potential substances for promoting alcohol metabolism. In addition, PAAS could also reduce the deleterious effects of alcohol by modulating unsaturated fatty acid biosynthesis, purine metabolism, and other metabolic pathways in the liver. These findings revealed the mechanisms by which PAAS promoted hepatic alcohol metabolism as well as protected the liver and provided a theoretical basis for exploring the mechanisms in honey synergistically promote alcohol metabolism.<\/jats:p>","DOI":"10.1002\/mnfr.202400539","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T13:39:40Z","timestamp":1740490780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Polyphenols and Ascorbic Acid in Honey From Diverse Floral Origins on Liver Alcohol Metabolism"],"prefix":"10.1002","volume":"69","author":[{"given":"Zhiwei","family":"Sun","sequence":"first","affiliation":[{"name":"Anhui Fermented Food Engineering Research Center School of Food and Biological Engineering Hefei University of Technology  Hefei City Anhui Province People's Republic of 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