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This systematic review evaluates associations between genotype and insulin response to an oral glucose tolerance test (OGTT) in terms of insulin area under the curve (AUC). Methods and results: Three electronic databases (Web of Science, Embase, PubMed) were searched for studies investigating associations between insulin AUC after an OGTT and single nucleotide polymorphisms (SNPs) belonging to the <jats:italic>transcription factor 7 like 2<\/jats:italic> (<jats:italic>TCF7L2<\/jats:italic>) gene, the <jats:italic>peroxisome proliferator\u2010activated receptor gamma<\/jats:italic> (<jats:italic>PPAR\u03b3<\/jats:italic>) gene, or the <jats:italic>potassium inwardly rectifying channel subfamily J member 11<\/jats:italic> (<jats:italic>KCNJ11<\/jats:italic>) gene in persons without diabetes. A total of 5199 articles were identified, of which 38 were included. Among them were family\u2010based studies (9), twin studies (2), and studies with unrelated participants (27). Seventeen articles investigated <jats:italic>TCF7L2<\/jats:italic> (7 SNPs), 14 investigated <jats:italic>PPAR\u03b3<\/jats:italic> (1 SNP), and 8 investigated <jats:italic>KCNJ11<\/jats:italic> (5 SNPs). For all investigated SNPs, at least half of the reports indicated no statistically significant association with postprandial insulin AUC. Conclusion: No evidence was found for associations between <jats:italic>TCF7L2<\/jats:italic>, <jats:italic>PPAR\u03b3<\/jats:italic>, and <jats:italic>KCNJ11<\/jats:italic> genotypes and insulin AUC after an OGTT. Future studies should investigate the effect of genetic risk scores on postprandial insulin.<\/jats:p>","DOI":"10.1002\/mnfr.202400561","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T03:36:28Z","timestamp":1737344188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations Between <i>TCF7L2<\/i>, <i>PPAR\u03b3<\/i>, and <i>KCNJ11<\/i> Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-3236","authenticated-orcid":false,"given":"Carmen P. 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