{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:48:00Z","timestamp":1792205280799,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.32360109"],"award-info":[{"award-number":["No.32360109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>At present, the incidence rate of ulcerative colitis (UC) continues to increase, causing a global burden. In addition, therapeutic drugs have great side effects. According to modern pharmacology, agarwood leaves have anti\u2010inflammatory, antibacterial, hypoglycemic, and lipid\u2010lowering effects. Therefore, this experiment on DSS induced colitis treatment of polyphenolic substances in agarwood leaves is feasible and in line with the current hot topic of using natural substances instead of drugs for treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>ALP supplementation promotes the expression of tight junction proteins occludin and Zonula occludens protein 1 (ZO\u20101) on colonic tissues, repairs the intestinal barrier, and relieves further colonic tissue damage. Besides, ALP effectively inhibits the activation of nuclear factor kappa\u2010B (NF\u2010\u043aB) signaling pathway and reduces the release of proinflammatory cytokines. Moreover, ALP reverses the alteration of gut microbiota in the colitic mice by increasing the abundances of Parabacteroides, Chlamydia, and Lachnospiraceae, and decreasing the abundances of Bacteroides and Phocaeicola. Furthermore, the correlation analysis suggested that ALP can attenuate DSS\u2010induced UC, which is probably related to the alterations in the gut microbiota.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ALP can ameliorate DSS\u2010induced UC by modulating gut microbiota, intestinal barrier function, and inflammatory responses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400566","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T06:55:06Z","timestamp":1732258506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phenolics\u2010Rich Extract from Agarwood Leaf\u2010Tea Alleviate Dextran Sulfate Sodium (DSS)\u2010Induced Ulcerative Colitis Via Modulating Intestinal Barrier Function, Liver Inflammation, and Gut Microbiota"],"prefix":"10.1002","volume":"68","author":[{"given":"Ruyan","family":"Fan","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering Hainan University  Haikou 570228 P. 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