{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:15:21Z","timestamp":1790709321124,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["16490"],"award-info":[{"award-number":["16490"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["184.034.019"],"award-info":[{"award-number":["184.034.019"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201906240049"],"award-info":[{"award-number":["201906240049"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>\n                      Cow's milk allergy (CMA) is one of the most prevalent food allergies in early childhood, often treated via elimination diets including standard\u00a0amino acid\u2010based formula or amino acid\u2010based formula supplemented with synbiotics (AAF or AAF\u2010S). This work aimed to assess the effect of cow's milk (CM) tolerance acquisition and synbiotic (inulin, oligofructose,\n                      <jats:italic>Bifidobacterium breve<\/jats:italic>\n                      M\u201016\u00a0V) supplementation on the fecal metabolome in infants with IgE\u2010mediated CMA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      The CMA\u2010allergic infants received AAF or AAF\u2010S for a year during which fecal samples were collected. The samples were subjected to metabolomics analyses covering gut microbial metabolites including SCFAs, tryptophan metabolites, and bile acids (BAs). Longitudinal data analysis suggested amino acids, BAs, and branched SCFAs alterations in infants who outgrew CMA during the intervention. Synbiotic supplementation significantly modified the fecal metabolome after 6 months of intervention, including altered purine, BA, and unsaturated fatty acid levels, and increased metabolites of infant\u2010type\n                      <jats:italic>Bifidobacterium<\/jats:italic>\n                      species: indolelactic acid and 4\u2010hydroxyphenyllactic acid.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study offers no clear conclusion on the impact of CM\u2010tolerance acquisition on the fecal metabolome. However, our results show that 6 months of synbiotic supplementation successfully altered fecal metabolome and suggest induced bifidobacteria activity, which subsequently declined after 12 months of intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202400583","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T06:57:41Z","timestamp":1733986661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the Fecal Metabolome in Infants With Cow's Milk Allergy: The Distinct Impacts of Cow's Milk Protein Tolerance Acquisition and of Synbiotic Supplementation"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5949-5746","authenticated-orcid":false,"given":"Pingping","family":"Zhu","sequence":"first","affiliation":[{"name":"Metabolomics and Analytics Centre Leiden Academic Centre for Drug Research Leiden University  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Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Belzer","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology Wageningen University  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2931-4295","authenticated-orcid":false,"given":"Amy C.","family":"Harms","sequence":"additional","affiliation":[{"name":"Metabolomics and Analytics Centre Leiden Academic Centre for Drug Research Leiden University  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hankemeier","sequence":"additional","affiliation":[{"name":"Metabolomics and Analytics Centre Leiden Academic Centre for Drug Research Leiden University  Leiden The 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