{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:50:40Z","timestamp":1780048240260,"version":"3.53.1"},"reference-count":55,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The study assesses the metabolic impact of dietary whey proteins across generations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method and results<\/jats:title><jats:p>Virgin females are fed 20% energy whey proteins with 70% energy carbohydrates, which reduces body weight gain and visceral adipose compared to controls fed dietary casein. In contrast, the males are unresponsive. The effect is accentuated in reproductive females that also have reduced plasma levels of glucose. The responsive females have increased cecal levels of pyruvic and lactic acid, suggesting a greater catabolism of carbohydrates in the gut. While the male and female offspring born to mothers on whey proteins continue to reduce body weight gain, the female offspring further decreases the visceral and subcutaneous tissues and increases the gut capacity to breakdown dietary carbohydrates and proteins, whereas the male offspring are able to only decrease the visceral and increase protein catabolism in the gut. The ileum of male mice responded by reducing the gene expression for fibroblast growth factor 15 and increasing the expression of chymotrypsinogen B1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The effect of whey proteins on growth can be passed from the mother to the offspring without a sex preference, whereas the transmission of gut activity and adiposity are dependent on the sex of the offspring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400584","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T06:16:48Z","timestamp":1730701008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Sex Dependent and Independent Effects of Dietary Whey Proteins Are Passed from the Mother to the Offspring"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-9457","authenticated-orcid":false,"given":"Kanishka N.","family":"Nilaweera","sequence":"first","affiliation":[{"name":"Food Bioscience Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"VistaMilk Research Centre Teagasc, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Nychyk","sequence":"additional","affiliation":[{"name":"Food Bioscience Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"McCarthy","sequence":"additional","affiliation":[{"name":"VistaMilk Research Centre Teagasc, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"Food Chemistry and Technology Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza P. D.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Food Bioscience Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"VistaMilk Research Centre Teagasc, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qusai M.","family":"Alabedallat","sequence":"additional","affiliation":[{"name":"Food Bioscience Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"VistaMilk Research Centre Teagasc, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Purfied","sequence":"additional","affiliation":[{"name":"Animal Bioscience Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Doyle","sequence":"additional","affiliation":[{"name":"Animal Bioscience Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cormican","sequence":"additional","affiliation":[{"name":"Animal and Grassland Research and Innovation Centre Teagasc, Grange  County Meath Dunsany C15 PW93 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Santos","sequence":"additional","affiliation":[{"name":"Teagasc Food Research Centre, Ashtown  Dublin D15 DY05 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Agriculture and Food Science Institute of Food and Health and Conway Institute, University College Dublin  Dublin D04 C1P1 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Tobin","sequence":"additional","affiliation":[{"name":"VistaMilk Research Centre Teagasc, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"Food Chemistry and Technology Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Speakman","sequence":"additional","affiliation":[{"name":"School of Biological Sciences University of Aberdeen  Aberdeen AB24 2TZ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donagh","family":"Berry","sequence":"additional","affiliation":[{"name":"VistaMilk Research Centre Teagasc, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"Animal Bioscience Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-7499","authenticated-orcid":false,"given":"Lorraine","family":"Brennan","sequence":"additional","affiliation":[{"name":"VistaMilk Research Centre Teagasc, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"School of Agriculture and Food Science Institute of Food and Health and Conway Institute, University College Dublin  Dublin D04 C1P1 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Cotter","sequence":"additional","affiliation":[{"name":"Food Bioscience Department Teagasc Food Research Centre, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"VistaMilk Research Centre Teagasc, Moorepark  County Cork Fermoy P61 C996 Ireland"},{"name":"APC Microbiome Ireland University College Cork  Cork T12 YT20 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxm012"},{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy055"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317609"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.139840"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109093"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01604-18"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13613"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00356.2016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-018-2640-5"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14867"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14523"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088904"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.6.0415"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114723"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00737-020-01046-8"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-020017"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-70178-3_2"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.190009"},{"key":"e_1_2_11_19_1","first-page":"241","volume":"5","author":"Varlamov O.","year":"2014","journal-title":"Front. Endocrinol."},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.117.153643"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.130252"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601752103"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113164"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513001396"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114514004024"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.04.052"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.20168"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.060"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20156487"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27187-7"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.10071"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.204.11.1925"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2007.2145"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600984"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1134082"},{"key":"e_1_2_11_36_1","first-page":"1","volume":"21","author":"He J.","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080763"},{"key":"e_1_2_11_38_1","first-page":"1","volume":"24","author":"Zhang L.","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14183809"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.7762\/cnr.2019.8.1.64"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8060351"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11061569"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.796661"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00134"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.13.5.398"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2012.08.005"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112541"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1764"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/1521654031000072148"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1069"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110979"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1006996"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.05.001"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121529"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027103"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202400584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T10:10:51Z","timestamp":1734516651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202400584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,3]]},"references-count":55,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/mnfr.202400584"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202400584","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,3]]},"assertion":[{"value":"2024-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400584"}}