{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T21:37:18Z","timestamp":1778189838733,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973898"],"award-info":[{"award-number":["81973898"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305305"],"award-info":[{"award-number":["82305305"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M733981"],"award-info":[{"award-number":["2023M733981"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ40578"],"award-info":[{"award-number":["2022JJ40578"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40799"],"award-info":[{"award-number":["2023JJ40799"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Scope<\/jats:bold>: Luteal phase deficiency (LPD) is the main cause of infertility without an effective cure. Quercetin (QUE) is a bioactive flavonoid with antioxidant properties, while its role in treating LPD remains unclear. This study aims to investigate the therapeutic effects of QUE on infertility and menstrual disorders induced by LPD, thus further exploring the underlying mechanism.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold>: Mifepristone\u2010induced rats are used to explore the protective effects of QUE against LPD. QUE stimulates the spontaneous secretion of progesterone to improve luteal function and endometrial receptivity in LPD rats by activating the kisspeptin\/GPR54 system to facilitate the gonadotropin\u2010releasing hormone (GnRH) pulsatility. Bioinformatics analysis reveals that the core mechanism of QUE in treating LPD is to attenuate the GnRH neuron pyroptosis by inhibiting the NF\u2010\u03baB pathway, which is further verified in LPD rats and lipopolysaccharide (LPS)\u2010treated GT1\u20107, as QUE significantly reduces the expression of key factors concerning NF\u2010\u03baB pathway and NOD\u2010like receptor family pyrin domain\u2010containing 3 (NLRP3) inflammasome.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: This study first proposes that neuron pyroptosis\u2010induced GnRH pulsatility disruption accounts for the pathogenesis of LPD, and QUE facilitates the pulse secretion of GnRH to boost the spontaneous progesterone secretion by inhibiting NF\u2010\u03baB\/NLRP3\u2010mediated neuron pyroptosis, which provides a new therapeutic target and strategy for LPD.<\/jats:p>","DOI":"10.1002\/mnfr.202400649","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T06:16:23Z","timestamp":1730700983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quercetin Boosts Pulsatile Gonadotropin\u2010Releasing Hormone Release to Improve Luteal Function via Inhibiting NF\u2010\u03baB\/NLRP3\u2010Mediated Neuron Pyroptosis"],"prefix":"10.1002","volume":"68","author":[{"given":"Yujie","family":"Shang","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences Central South University  Changsha China"},{"name":"School of Chinese Medicine Hubei University of Chinese Medicine  Wuhan China"},{"name":"Hubei Shizhen Laboratory  Wuhan China"},{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Han","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute Central South University  Changsha China"},{"name":"NHC Key Laboratory of Carcinogenesis, Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4703-7651","authenticated-orcid":false,"given":"Minghua","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences Central South University  Changsha China"},{"name":"Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute Central South University  Changsha China"},{"name":"NHC Key Laboratory of Carcinogenesis, Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001356"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.892753"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2004.08.007"},{"key":"e_1_2_9_4_1","volume":"8","author":"Salang L.","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/hmbci-2019-0067"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.519572"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7464"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6750"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2256001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21461"},{"key":"e_1_2_9_12_1","first-page":"7","volume-title":"Guidance for Industry: Estimating the Maximum Safe Starting Dose in Adult Healthy Volunteer","author":"U.S. Department of Health and Human Services","year":"2005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.05.008"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0363-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167301"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2016.07.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020529"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0363-7"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.70"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00009.2019"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.05.008"},{"key":"e_1_2_9_22_1","first-page":"424","volume":"3","author":"Hu Y.","year":"2015","journal-title":"J. Hainan Med. Coll."},{"key":"e_1_2_9_23_1","first-page":"1883","volume":"10","author":"Yang L.","year":"2017","journal-title":"Prog. Mod. Biomed."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08907-9"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1228"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.03.051"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107533108"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351867"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12143"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2011.01800.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202211370"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121720"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03450"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122232"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210895"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.202400649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T12:13:11Z","timestamp":1732882391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.202400649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":35,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/mnfr.202400649"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.202400649","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2024-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2400649"}}