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Alzheimer's disease (AD) and other neurological disorders are far more likely to develop as people age. AD is a gradual, irreversible, and degenerative brain disorder that progressively deteriorates memory and cognitive function, eventually leading to death. Treatment for AD is the most significant unmet clinical need in neurology. There are no effective treatment options to prevent or reverse the degenerative process. The current medical management focuses primarily on temporarily easing symptoms, with little or no overall improvement. Although genetic predisposition and lifestyle factors influence the risk of neurodegenerative disorders, recent research suggests that dietary polyphenols with solid antioxidant capacities play crucial roles in determining brain health and aging. <jats:italic>Aspalathus linearis<\/jats:italic> is used to produce Rooibos, a popular South African herbal tea, which may modulate neurodegenerative mechanisms such as oxidative stress, tau protein, amyloid plaques, inflammation, and metals, all of which have been associated with AD. We reviewed the literature to evaluate the potential neuroprotective effects of Rooibos and its major flavonoids and to understand the underlying molecular mechanisms.<\/jats:p>","DOI":"10.1002\/mnfr.202400670","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T07:37:38Z","timestamp":1734680258000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Neuroprotective Effect of Rooibos Herbal Tea Against Alzheimer's Disease: A Review"],"prefix":"10.1002","volume":"69","author":[{"given":"Elias","family":"Chipofya","sequence":"first","affiliation":[{"name":"Applied Microbial and Health Biotechnology Institute Cape Peninsula University of Technology  Cape Town South Africa"},{"name":"Department of Biomedical Sciences Faculty of Health Sciences and Wellness Sciences Cape Peninsula University of Technology  Cape Town South 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