{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:22Z","timestamp":1786978222265,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Obesity by high\u2010fat diets (HFDs) is a chronic metabolic disorder that poses a significant threat to human health. Tea polyphenols (TPs) can prevent obesity caused by HFD by modulating gut microbiota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      To explore the function of TP in mitigating the effects of obesity and inflammation, mice are fed HFDs either with or without TP. TP supplementation effectively attenuates HFD\u2010induced weight gain, liver and adipose tissue accumulation, while also improving liver fat content as well as colon and ileum tissue morphology. TP supplementation leads to a downregulation of lipid accumulation genes and an upregulation of lipid\u2010decomposition genes. Moreover, TP increases\n                      <jats:italic>Blautia<\/jats:italic>\n                      and\n                      <jats:italic>Faecalibaculum<\/jats:italic>\n                      while reducing the\n                      <jats:italic>Colidextribacter<\/jats:italic>\n                      and short\u2010chain fatty acids in HFD\u2010induced mice, significantly activates G protein\u2010coupled receptors, inhibits histone deacetylases, enhances intestinal tight junction expression levels, reduces intestinal permeability, and thereby preserves intestinal barrier integrity. Additionally, TP markedly suppresses the expression of inflammatory cytokines and inhibits the activation of TLR4 signaling pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that TP holds great promise for improving both obesity management and alleviating intestinal inflammation, and provides a clue for understanding the antiobesity effects of TP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.202400685","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:04:39Z","timestamp":1732248279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Tea Polyphenols Reduced Obesity by Modulating Gut Microbiota\u2010SCFAs\u2010Barrier and Inflammation in High\u2010Fat Diet\u2010Induced Mice"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-8206","authenticated-orcid":false,"given":"Baoming","family":"Tian","sequence":"first","affiliation":[{"name":"College of Food Science and Technology Zhejiang University of Technology  Huzhou 313299 China"},{"name":"Tea Research Institute Chinese Academy of Agricultural Sciences  Hangzhou 310018 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinjiao","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Zhejiang University of Technology  Huzhou 313299 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhu","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Zhejiang University of Technology  Huzhou 313299 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gu","sequence":"additional","affiliation":[{"name":"Genhawk (Wuhan) Biotech Company Limited  Wuhan 430074 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology Zhejiang University of Technology  Huzhou 313299 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxun","family":"Wei","sequence":"additional","affiliation":[{"name":"Hangzhou Vocational &amp; 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