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Arg. (MPMA) is a specialty plant used to make tea in Hainan Province, China. However, its hypolipidemic activity has been rarely studied. In this study, three polyphenol fractions (MPMAP\u20101, MPMAP\u20102, and MPMAP\u20103) were purified from a 60% ethanol extract of MPMA, and the hypolipidemic activities were evaluated by establishing an FFA\u2010induced L02 cell model to determine lipid accumulation, antioxidant enzyme activities, and gene levels related to the Nrf2\/ARE pathway and lipid metabolism. In addition, noninduced and high glucose\u2010induced models were established using <jats:italic>Caenorhabditis elegans<\/jats:italic> (<jats:italic>C. elegans<\/jats:italic>) to evaluate the lipid\u2010lowering activity of MPMAP\u20101. The results showed that all three polyphenols could significantly inhibit lipid accumulation, reduce intracellular MDA content, and enhance the activities of CAT, SOD, and GPx in FFA\u2010induced L02 cells. The qRT\u2010PCR results indicated that the amount of fat accumulation in L02 cells could be regulated by modulating the relative expression of mRNA in the Nrf2\/ARE signaling pathway and lipid metabolism pathway. The noninduced model and high glucose\u2010induced model demonstrated that MPMAP\u20101 was able to reduce lipid accumulation and ROS levels and increase the activities of antioxidant enzymes in <jats:italic>C. elegans<\/jats:italic>. In summary, our results suggested that polyphenol compounds of MPMA may be a promising natural product for lipid\u2010lowering.<\/jats:p>","DOI":"10.1002\/mnfr.202400689","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T07:00:21Z","timestamp":1744268421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polyphenols From <i>Mallotus peltatus<\/i> (Geiseler) Mull. Arg. Ameliorates FFA\u2010Induced Hepatic Steatosis in L02 Cells and Reduces Lipid Accumulation in <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1002","volume":"69","author":[{"given":"Ke\u2010Xin","family":"Hao","sequence":"first","affiliation":[{"name":"College of Food and Bioengineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Meng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering South China University of Technology  Guangzhou China"},{"name":"Dermatology Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui\u2010Fang","family":"Zhong","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College Guangzhou University of Chinese Medicine  Shenzhen China"},{"name":"Department of Intensive Care Unit Shenzhen Traditional Chinese Medicine Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College Guangzhou University of Chinese Medicine  Shenzhen China"},{"name":"Department of Intensive Care Unit Shenzhen Traditional Chinese Medicine Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3361-6149","authenticated-orcid":false,"given":"Jian\u2010Guo","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Food and Bioengineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1165-634X","authenticated-orcid":false,"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04399"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.342"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2008.12.015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.055"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R400010-JLR200"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2664"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339908786241133"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39385.413113.25"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S392684"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/app12168342"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1703109"},{"key":"e_1_2_8_13_1","article-title":"Long\u2010Term Effects of Weight\u2010Reducing Drugs in People With Hypertension","volume":"1","author":"Siebenhofer A.","year":"2021","journal-title":"Cochrane Database of Systematic Review"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115378"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.21273\/HORTSCI14079-19"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10092130"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.03.099"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00379-3"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-98"},{"key":"e_1_2_8_20_1","first-page":"878","article-title":"Comparison of Anti\u2010Atherosclerotic Effects of Two Different Extracts From Leaves of Mallotus Furetianus, Asian Pac","volume":"4","author":"Liu Y. 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