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In this study, cationic lipid\u2010assisted nanoparticles loaded with \u03b2\u2010carotene (NP\u2010BC) and naringenin (NP\u2010NAR), respectively, were fabricated and characterized, and their digestive and metabolic behaviors were evaluated using static digestion models and in vivo imaging. The particle size and potential of cationic polymer nanoparticles changed during digestion but retained their structural integrity, which was conducive to targeted drug delivery to the liver and prolonged the in vivo circulation of the drug. It is noteworthy that whereas NP\u2010BC was more advantageous in lowering hepatic fat deposition, NP\u2010NAR successfully limited weight gain. This study proved that cationic polymer nanoparticles are promising carriers for transporting natural hydrophobic antioxidants and may be beneficial for improving nutrition absorption and targeted delivery to alleviate metabolic dysfunction\u2010associated steatotic liver disease (MASLD) symptoms.<\/jats:p>","DOI":"10.1002\/mnfr.202400703","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:06:09Z","timestamp":1740121569000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cationic Lipid\u2010Assisted PEG\u2010\n                    <i>b<\/i>\n                    \u2010PLA Nanoparticles Achieve Long\u2010Lasting Targeted Delivery of Natural Hydrophobic Antioxidants"],"prefix":"10.1002","volume":"69","author":[{"given":"Lu","family":"Dong","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiqing","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering South China University of Technology, Guangzhou International Campus  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyong","family":"Lou","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congfei","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering South China University of Technology, Guangzhou International Campus  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-0176","authenticated-orcid":false,"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101640"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158635"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-022-10443-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2022.102750"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120752"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14938"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.030"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM01469J"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.09.021"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c00148"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.12.044"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194377"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01420F"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-018-2007-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.02.121"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-325-1_15"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-016-0537-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.07.035"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.138346"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b04879"},{"key":"e_1_2_8_22_1","unstructured":"R. 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