{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:48:25Z","timestamp":1792291705842,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012620","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202211172"],"award-info":[{"award-number":["tsqn202211172"]}],"id":[{"id":"10.13039\/100012620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Inflammatory bowel disease (IBD) is a chronic condition characterized by gut inflammation causing persistent diarrhea and abdominal pain. Despite the nutritional benefits of wolfberry honey (from <jats:italic>Lycium barbarum<\/jats:italic> L.), its potential to alleviate IBD remains underexplored. This study evaluated the protective effects of wolfberry honey and its extract (wolfberry honey extract [WHE]) against dextran sulfate sodium (DSS)\u2010induced ulcerative colitis (UC) using in vivo and in vitro models. Mice pretreated with wolfberry honey showed significant symptom improvement in DSS\u2010induced UC, linked to reduced expression of proinflammatory markers (Il\u20101\u03b2, Il\u20106, Tnf\u2010\u03b1, and Mcp\u20101) and increased antioxidant genes (<jats:italic>Nrf2<\/jats:italic>, <jats:italic>Sod2<\/jats:italic>). Increased Occludin levels indicated improved intestinal barrier function. In vitro, WHE protected DSS\u2010treated Caco\u20102 cells by lowering reactive oxygen species (ROS), stabilizing mitochondrial membrane potential, and inhibiting TLR4\/NF\u2010\u03baB signaling. It enhanced the expression of antioxidant genes and tight junction proteins (ZO\u20101, Occludin, and Claudin\u20101). Metabolomic analysis revealed that WHE modulated glycerophospholipid metabolism, increasing phosphatidylcholine and choline levels and decreasing lysophosphatidylcholine levels. These results highlight the potential of wolfberry honey and its extract as nutraceuticals for managing UC through their effects on inflammation, oxidative stress, and intestinal barrier function. Further research is warranted to elucidate their mechanisms of action and assess their long\u2010term therapeutic benefits in IBD management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202400726","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T07:24:46Z","timestamp":1734506686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Wolfberry Honey and Its Extract Alleviate Dextran Sodium Sulfate\u2010Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Reducing Oxidative Stress and Inflammation"],"prefix":"10.1002","volume":"69","author":[{"given":"Jie","family":"Yuan","sequence":"first","affiliation":[{"name":"College of Agriculture and Biology Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biology Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyang","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biology Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biology Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biology Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biology Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7823-1488","authenticated-orcid":false,"given":"Hongzhuan","family":"Xuan","sequence":"additional","affiliation":[{"name":"College of Agriculture and Biology Liaocheng University  Liaocheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-015-0439-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S65979"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303955"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6542a3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab089"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14422"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11111551"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.684486"},{"key":"e_1_2_9_10_1","first-page":"194","article-title":"Chemical Composition and Uses of Honey: A Review","volume":"4","author":"Tafere D. 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