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Although several drugs are available for the treatment of HUA, they have been associated with undesirable side effects. Therefore, this study aims to evaluate the therapeutic effects of sunflower head extract (KHE) on HUA in a mouse model and explore its potential mechanisms. All mice were randomly divided into three groups: Normal control (NC, 0.5% CMC\u2010Na), HUA model (MD, yeast extract paste 20\u00a0g\/kg), and KHE treatment group (KHE, 1\u00a0g\/kg). Biochemical indicators, the oxidative stress state, and metabolomics were analyzed. KHE reduced the levels of 5\u2010aminoimidazole ribonucleotide, xanthine, hypoxanthine, and uric acid in the serum of mice with HUA but increased the levels of adenine and taurine. KHE decreased the activities of superoxide dismutase (SOD) enzymes, the hepatic hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) and malondialdehyde (MDA) levels, and the serum levels of betaine aldehyde and beta\u2010D\u2010glucosamine. KHE improved oxidative stress levels and mitigated potential damage to the kidneys and joints caused by urate deposition. These findings provide comprehensive evidence supporting the anti\u2010HUA effects and underlying mechanisms of KHE in HUA mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.202401017","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T10:16:50Z","timestamp":1739269010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolomics Reveal the Anti\u2010Hyperuricemia Effects and Mechanisms of Sunflower Head Extract in Hyperuricemia Mice Model"],"prefix":"10.1002","volume":"69","author":[{"given":"Gang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine, Public Health College Qiqihar Medical University  Qiqihar Heilongjiang China"},{"name":"Qiqihar Academy of Medical Sciences  Qiqihar Heilongjiang China"},{"name":"Postdoctoral Research Station of Qiqihar Institute of Medical Science  Qiqihar Heilongjiang 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