{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:44:09Z","timestamp":1790289849947,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Fecal volatile organic compounds (VOCs) offer insights into gut microbiota function that may drive the pathogenesis of ulcerative colitis (UC). This cross\u2010sectional study aimed to compare dietary intake and VOC patterns in UC patients with an ileoanal pouch compared to those with an intact colon. Seven\u2010day food records and fecal samples were collected from UC patients with an intact colon (<jats:italic>n<\/jats:italic>\u00a0=\u00a028) or an ileoanal pouch (<jats:italic>n<\/jats:italic>\u00a0=\u00a011). Fecal VOC profiles were analyzed using gas chromatography\u2010mass spectrometry. Dietary intake in both groups was largely similar. The mean Jaccard similarity index of VOC was 0.55 (95% CI:0.53, 0.56) in the pouch compared with 0.48 (0.47, 0.49) in the colon group (<jats:italic>p<\/jats:italic> &lt; 0.01). A lower proportion of VOC classes was detected in the pouch, including sulfide (9%\u00a0vs. 57%; <jats:italic>p<\/jats:italic> &lt; 0.01), branched\u2010chain fatty acids (BCFAs; 45%\u201364% vs. 93%\u201396%; <jats:italic>p<\/jats:italic> &lt; 0.01), and ketones (45%\u201364% vs. 93%\u201396%; <jats:italic>p<\/jats:italic> &lt; 0.01), along with a higher proportion of butyric acid (91%\u00a0vs. 29%; <jats:italic>p<\/jats:italic> &lt; 0.001). Unrelated to diet, VOC profiles show less functional diversity, reduced protein and greater carbohydrate fermentation, and altered production of secondary metabolites in the UC\u2010pouch compared with the intact colon. These differences in the metabolic environment of the gut microbiota provide insights into pathogenesis and suggest that microbial\u2010targeted interventions should be tailored accordingly.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.70003","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:55:25Z","timestamp":1741733725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Distinct Profiles of Fecal Volatile Organic Compounds Discriminate Ulcerative Colitis Patients With an Ileoanal Pouch From Those With an Intact Colon"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-2457","authenticated-orcid":false,"given":"Chu K.","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology School of Translational Medicine Monash University and Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kraig","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Cancer Medicine University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Day","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Service Department of Gastroenterology The Queen Elizabeth Hospital  South Australia Australia"},{"name":"Basil Hetzel Research Institute  South Australia Australia"},{"name":"School of Medicine and Health Sciences University of Adelaide  North Terrace Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaid M.","family":"Ardalan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Translational Medicine Monash University and Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Slater","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Cancer Medicine University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V.","family":"Bryant","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Service Department of Gastroenterology The Queen Elizabeth Hospital  South Australia Australia"},{"name":"Basil Hetzel Research Institute  South Australia Australia"},{"name":"School of Medicine and Health Sciences University of Adelaide  North Terrace Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Translational Medicine Monash University and Alfred Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Probert","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Cancer Medicine University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"573","article-title":"Gut Microbiota and IBD: Causation or Correlation?","volume":"14","author":"Ni J.","year":"2017","journal-title":"Gastroenterology & 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