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In the present study, we aimed to investigate the bone\u2010protective and anti\u2010osteoporotic effects of resveratrol in rats with chronic kidney disease\u2010induced osteoporosis. The 5\/6th nephrectomy (Nx) model of CKD was established. Resveratrol and alendronate (ALN), as standard drug, were administered for 45 days. Blood samples and femurs were collected and subjected to molecular analysis, micro\u2010CT, and bone mechanical tests. The results showed a significant decrease in Ca levels but no significant changes in 1,25 vitamin D and phosphorus levels in untreated and treated CKD groups. Treatment with RES and ALN did not reverse the increase of serum parathyroid hormone while reducing the elevated FGF\u201023 levels. Unlike ALN, RES had no significant effect on increased alkaline phosphatas levels or decreased osteocalcin and OPG levels in CKD rats. Moreover, results showed that RES reversed the increase of RANKL and TRAP in serum and femur tissue close to the control level, leading to an improvement in bone strength and microarchitecture. In conclusion, the present study showed beneficial anti\u2010osteoporotic effects of RES on CKD\u2010induced osteoporosis.<\/jats:p>","DOI":"10.1002\/mnfr.70017","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:39:18Z","timestamp":1741757958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anti\u2010Osteoporosis and Bone Protective Effects of Resveratrol in Rats With Chronic Kidney Disease\u2010Induced Osteoporosis"],"prefix":"10.1002","volume":"69","author":[{"given":"Enzhe","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanxi Bethune Hospital(Shanxi Academy of Medical Sciences) Third Hospital of Shanxi Medical University Tongji Shanxi Hospital  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanxi Bethune Hospital(Shanxi Academy of Medical Sciences) Third Hospital of Shanxi Medical University Tongji Shanxi Hospital  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanxi Bethune Hospital(Shanxi Academy of Medical Sciences) Third Hospital of Shanxi Medical University Tongji Shanxi Hospital  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5833-5151","authenticated-orcid":false,"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Shanxi Provincial People's Hospital  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dou","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanxi Bethune Hospital(Shanxi Academy of Medical Sciences) Third Hospital of Shanxi Medical University Tongji Shanxi Hospital  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000411"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8852690"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-018-0491-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3485785"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241201"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117126"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"1558","article-title":"Executive Summary of the 2017 KDIGO Chronic Kidney Disease\u2010Mineral and Bone Disorder (CKD\u2010MBD) Guideline Update: What's Changed and Why It Matters","volume":"92","author":"Ketteler M.","year":"2017","journal-title":"Kidney International"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO03867B"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00981"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G226"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12618"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.11.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.05.009"},{"issue":"5","key":"e_1_2_9_15_1","first-page":"5032","article-title":"Protective Effects of Resveratrol on Osteoporosis Via Activation of the SIRT1\u2011NF\u2011\u03baB Signaling Pathway in Rats Experimental and Therapeutic Medicine","volume":"14","author":"Wang X.","year":"2017","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103262"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-04595-1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10070429"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0651"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6125871"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2005.8.14"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.46.78"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513003115"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmu103"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2005.09.005"},{"issue":"3","key":"e_1_2_9_26_1","first-page":"167","article-title":"Effects of 5\/6 Nephrectomy on Renal Function and Blood Pressure in Mice","volume":"4","author":"Gava A. 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