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Rats were assigned into five groups; Control, MSG (400\u00a0mg\/kg), MY (200\u00a0mg\/kg), FC+MSG (received FC plus MSG), and FC+MY group (received FC plus MY). The antioxidant properties of FC were evaluated. The results revealed the antioxidant potency of FC leave extract. MSG\/MY evoked a hepato\u2010renal injury indicated by marked elevations in their biochemical functions. Besides, oxidative damage was also initiated represented by significant increases in MDA levels and decreases in GSH content and SOD activity accompanied by apoptotic cascade (increases in Bax\/Bcl2 ratio and caspase3 expression). The molecular docking ascertained the interaction between MSG\/MY and cellular antioxidants. However, FC was able to reduce the MSG\/MY\u2010induced oxidative stress, apoptosis, and histopathological alterations as well as improve the liver and kidney functions. In the molecular docking model, the natural bioactive compounds of FC explored high affinities for binding with Bax and caspase\u20103 abrogating the induced apoptosis. The antioxidant potential of FC mitigated the hepato\u2010renal damage in rats caused by MSG or MY.<\/jats:p>","DOI":"10.1002\/mnfr.70030","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T07:14:48Z","timestamp":1747034088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preferential Therapeutic Potential of <i>Ficus carica<\/i> Against Monosodium Glutamate and Metanil Yellow\u2010Evoked Hepato\u2010Renal Injury: In Vivo and In Silico Approaches"],"prefix":"10.1002","volume":"69","author":[{"given":"Hanaa M.","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Agricultural Chemistry Faculty of Agriculture Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4907-955X","authenticated-orcid":false,"given":"Ahmed","family":"Abdeen","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology Faculty of Veterinary Medicine Benha University Toukh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda E.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Agricultural Chemistry Faculty of Agriculture Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal H.","family":"Almohammadi","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science Faculty of Medicine Taibah University Madinah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.","family":"Abdel\u2010Daim","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Pharmacy Program Batterjee Medical College Jeddah Saudi Arabia"},{"name":"Department of Pharmacology Faculty of Veterinary Medicine Suez Canal University Ismailia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-4360","authenticated-orcid":false,"given":"Ali H.","family":"El\u2010Far","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Veterinary Medicine Damanhour University Damanhour Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donia E. 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