{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:54:56Z","timestamp":1791644096947,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Bangle, a perennial herb belonging to the ginger family with antiinflammatory properties, has been under\u2010researched in ulcerative colitis. This study aimed to investigate the effects of Bangle extract (BaE) on inflammation and autophagy in the colons of mice with dextran sulfate sodium (DSS)\u2010induced colitis. Male C57BL\/6J mice were assigned to four groups: control, DSS\u00a0+\u00a00% BaE, DSS\u00a0+\u00a01% BaE, and DSS\u00a0+\u00a03% BaE. The BaE groups were fed BaE diets for 3 weeks, followed by an additional week of BaE diets and 3% DSS in the water. The control group received a standard chow diet and water for 4 weeks. Plasma leucine\u2010rich \u03b12\u2010glycoprotein (LRG) levels, macrophage count, and the levels of nuclear factor kappa B (NF\u03baB) p65, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), adenosine monophosphate\u2010activated protein kinase (AMPK), peroxisome proliferator\u2010activated receptor \u03b3 coactivator\u20101\u03b1 (PGC\u20101\u03b1), mechanistic target of rapamycin (mTOR), and autophagy markers were analyzed. In the DSS\u00a0+\u00a00% BaE group, LRG levels, macrophage count, NF\u03baB p65 protein, and TNF\u2010\u03b1 mRNA levels were significantly higher compared to the control group. However, in the DSS\u00a0+\u00a03% BaE group, these levels were significantly reduced. Additionally, PGC\u20101\u03b1 and phosphorylated AMPK levels were increased, while phosphorylated mTOR levels decreased, and autophagy marker microtubule\u2010associated protein 1 light chain 3B (LC3B)\u2010II levels were increased in the DSS\u00a0+\u00a03% BaE group. BaE may ameliorate colonic inflammation and upregulate autophagy via the modulation of the AMPK\/mTOR\/NF\u03baB pathway in DSS\u2010induced colitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.70034","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:06:21Z","timestamp":1743811581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bangle (<i>Zingiber purpureum<\/i> Rosc.) Extract Ameliorates Colonic Inflammation and Upregulates Autophagy via the Modulation of the AMPK\/mTOR\/NF\u03baB Pathway in a Mouse Colitis Model"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8616-5828","authenticated-orcid":false,"given":"Shiho","family":"Kasai","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences Aomori University of Health and Welfare  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anishma","family":"Karmacharya","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Aomori University of Health and Welfare  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4394-8710","authenticated-orcid":false,"given":"Yuuka","family":"Mukai","sequence":"additional","affiliation":[{"name":"School of Nutrition and Dietetics, Faculty of Health and Social Work Kanagawa University of Human Services  Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Sato","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Aomori University of Health and Welfare  Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1323","article-title":"Ulcerative Colitis: Diagnosis and Treatment","volume":"76","author":"Langan R. 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