{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:36:18Z","timestamp":1773419778773,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Omega\u20103 polyunsaturated fatty acids (PUFA) and polyphenols have attracted interest to counteract ocular diseases and more specifically age\u2010related macular degeneration (AMD). This eye disease, which is the leading cause of irreversible blindness in industrialized countries, is characterized by damage to the central part of the retina, the macula. Despite therapeutic advances with the use of anti\u2010vascular endothelial growth factor (VEGF) monoclonal antibodies, numerous resistance mechanisms that worsen visual impairment have been identified. In this context, we highlight the exceptional potential of polyphenols and PUFA in addressing AMD through their actions on the different molecular mechanisms involved in AMD progression. More specifically, this review focuses on the current understanding of the effects of resveratrol, as well as docosahexaenoic and eicosapentaenoic acids, two prominent omega\u20103 PUFA, and the combination of these compounds. We also discuss the limitations and explore future directions for the combined use of these natural products as preventive or complementary therapies to preserve vision and slow disease progression.<\/jats:p>","DOI":"10.1002\/mnfr.70037","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T04:52:52Z","timestamp":1744001572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Current Advances in the Combination of Fatty Acids and Resveratrol to Fight Ocular Diseases"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-8499","authenticated-orcid":false,"given":"Dominique","family":"Delmas","sequence":"first","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe  Dijon France"},{"name":"INSERM Research Center UMR1231 \u2010 Therapies and Immune Response in Cancers Team Bioactive Molecules and Health Research Group  Dijon France"},{"name":"Centre de Lutte Contre le Cancer Georges Fran\u00e7ois Leclerc  Dijon France"},{"name":"INSERM UMS58 Biologie Sant\u00e9 Dijon BioSanD  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maude","family":"Perus","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe  Dijon France"},{"name":"INSERM Research Center UMR1231 \u2010 Therapies and Immune Response in Cancers Team Bioactive Molecules and Health Research Group  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Aires","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe  Dijon France"},{"name":"INSERM Research Center UMR1231 \u2010 Therapies and Immune Response in Cancers Team Bioactive Molecules and Health Research Group  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5549-1992","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Hermetet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Bourgogne Europe  Dijon France"},{"name":"INSERM Research Center UMR1231 \u2010 Therapies and Immune Response in Cancers Team Bioactive Molecules and Health Research Group  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-83880-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1171507"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30041-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152012802650048"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2741\/afaq"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152012802650093"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60282-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.03.083"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.11.027"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000657"},{"key":"e_1_2_10_12_1","first-page":"353","article-title":"Age\u2010Related Macular Degeneration (AMD): Pathogenesis and Therapy","volume":"58","author":"Nowak J. 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