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Sixty male C57BL\/6 mice were divided into six groups, receiving either a control diet, high\u2010fiber diet, or acetate supplementation alongside alcohol treatment. Results revealed that cardiac fibrosis and heart failure were notably improved in the AHD mice receiving high\u2010fiber or acetate diets. Transcriptomic analyses indicated that dietary interventions modulated the expression of genes involved in lipid metabolism and the TGF\u2010\u03b2 signaling pathway. Additionally, 16S rRNA sequencing showed that the high\u2010fiber diet and acetate altered gut microbiota composition, enhancing the abundance of beneficial bacteria such as <jats:italic>Akkermansia muciniphila<\/jats:italic>, <jats:italic>Lactobacillus intestinalis<\/jats:italic>, and <jats:italic>Bacteroides acidifaciens<\/jats:italic>. These microbes exhibited positive correlations with genes related to fat metabolism and TGF\u2010\u03b2 signaling, suggesting a potential mechanism for gut microbiota's role in AHD pathology. ROC analysis identified these bacteria as promising biomarkers for AHD detection. Overall, our findings underscore the therapeutic potential of dietary fiber and acetate in modulating gut microbiota and improving cardiac function in AHD, highlighting the intricate relationship between gut health and cardiovascular disease management.<\/jats:p>","DOI":"10.1002\/mnfr.70040","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T08:11:51Z","timestamp":1744963911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Dietary Fiber and Acetate on Alcoholic Heart Disease and Intestinal Microbes in Mice"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-7306","authenticated-orcid":false,"given":"Wei","family":"Siang","sequence":"first","affiliation":[{"name":"College of Life Science Shanxi Agricultural University  Jinzhong People's Republic of China"},{"name":"Beijing Medi Intelligent Pharmaceutical Technology Co. 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