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This study set out to explore its potential impact on type 2 diabetic osteoporosis (T2DOP). MC3T3\u2010E1 cells were exposed to a high\u2010glucose environment to simulate diabetic conditions. Treatment with ARC increased the expression of crucial osteogenic transcription factor genes, such as RUNX2, Osterix, and COL1A1. Moreover, ARC mitigated the production of ROS induced by high glucose levels. For in vivo experimentation, db\/db mice were used as models for T2DOP. ARC supplementation decreased bone loss and improved bone structural integrity. Collectively, our findings indicate that ARC holds promise as a nutritional intervention for the treatment of T2DOP. By activating the Nrf2\/HO\u20101 signaling pathway, ARC could help counteract oxidative stress and impaired bone differentiation associated with diabetes, thus offering a potential dietary strategy to support bone health. Incorporating ARC\u2010containing foods or supplements into the diet could be a beneficial approach to enhance overall bone quality and potentially reduce the risk of fractures and other bone\u2010related problems in patients with diabetes, highlighting the importance of considering natural compounds for the nutritional management of chronic diseases.<\/jats:p>","DOI":"10.1002\/mnfr.70053","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T23:45:50Z","timestamp":1743810350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arctiin Inhibits Hyperglycemia\u2010Induced Oxidative Stress by Activating the Nrf2\/HO\u20101 Signaling Pathway to Treat Type 2 Diabetic Osteoporosis"],"prefix":"10.1002","volume":"69","author":[{"given":"Weipeng","family":"Sun","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou Guangdong Province 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