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Since the discovery of leptin in 1994, WAT has been recognized as a dynamic endocrine organ for secreting a series of molecules with hormonal functions, collectively called adipokines. The link between obesity, WAT, adipokines, and the male reproductive system is direct and little explored. With changes in nutritional status, WAT undergoes morphofunctional changes, and the secretion of adipokines is altered, negatively impacting reproductive mechanisms, including steroidogenesis and spermatogenesis. In this review, we address in an updated way the structural and functional characteristics of WAT as well as the link between obesity and changes in the signaling pathways of the adipokines leptin, adiponectin, resistin, visfatin, apelin, chemerin, omentin\u20101, vaspin, and asprosin in male reproduction. Understanding the relationship between obesity, these adipokines, and reproductive dysfunction can contribute to new strategies for the treatment of subfertility and male infertility.<\/jats:p>","DOI":"10.1002\/mnfr.70054","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:09:46Z","timestamp":1744110586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Obesity, White Adipose Tissue, and Adipokines Signaling in Male Reproduction"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-6604","authenticated-orcid":false,"given":"Fabiane Ferreira","family":"Martins","sequence":"first","affiliation":[{"name":"Department of Morphology Federal University of Rio Grande do Norte  Natal Rio Grande do Norte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria do Socorro 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