{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:00:57Z","timestamp":1787313657400,"version":"build-2736575974"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473578"],"award-info":[{"award-number":["82473578"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82192884"],"award-info":[{"award-number":["82192884"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The gastrointestinal tract is highly sensitive to ionizing radiation (IR), which causes radiation\u2010induced intestinal injury (RIII). There are no effective drugs available for RIII in routine clinical treatment, which is a major limiting factor during the process of radiotherapy for pelvic abdominal malignancies. In this study, we aimed to elucidate the potential of probiotic\n                    <jats:italic>Bacillus coagulans<\/jats:italic>\n                    BC99 (\n                    <jats:italic>B.coagulans<\/jats:italic>\n                    BC99) in preventing RIII. C57BL\/6J mice were gavage\u2010administered with\n                    <jats:italic>B.coagulans<\/jats:italic>\n                    BC99 for 30 days and then exposed to a single dose of 12\u00a0Gy x\u2010ray whole abdominal irradiation (WAI).\n                    <jats:italic>B.coagulans<\/jats:italic>\n                    BC99 treatment could mitigate RIII by preventing weight loss, maintaining the integrity of intestinal structure and barrier, improving inflammatory symptoms, modulating oxidative stress, and regulating the composition of gut microbiota, thereby reestablishing intestinal homeostasis. In addition, the potential radioprotective mechanism of\n                    <jats:italic>B.coagulans<\/jats:italic>\n                    BC99 was closely related to the gut microbiota\u2010derived metabolites. This study offers a novel perspective for advancing probiotic\u2010based treatments for RIII and enhancing strategies for the prevention of RIII.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70057","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:05:33Z","timestamp":1744884333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Bacillus Coagulans<\/i>\n                    BC99 Protects Ionizing Radiation\u2010Induced Intestinal Injury and Modulates Gut Microbiota and Metabolites in Mice"],"prefix":"10.1002","volume":"69","author":[{"given":"Lin\u2010Feng","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection Key Laboratory of Radiation Damage and Treatment of Jiangsu Provincial Universities and Colleges Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions School 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