{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:15:28Z","timestamp":1789784128055,"version":"4.0.1"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The role of DNA methylation (DNAm) and its modulation by dietary factors in gestational diabetes mellitus (GDM) remains underexplored, particularly in marginalized populations. This study investigates DNAm alterations in GDM\u2010exposed cord blood and placenta and their association with maternal dietary quality and single nutrient intake in a low\u2010income population from the Myanmar\u2013Thailand border. A matched case\u2013control design (GDM:\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a038, controls:\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a034) was selected from a Myanmar\u2013Thailand pregnancy cohort. Dietary intake was assessed via 24\u2010h recalls and analyzed using Nutritionist Pro, with dietary quality evaluated by the healthy eating index (HEI). DNAm was profiled in 72 cord blood and 72 placental samples using the Infinium MethylationEPIC array. Significant differences in dietary vitamin D, total folate, and saturated fat intake were observed between the groups. RnBeads analyses revealed hypomethylation as the predominant DNAm pattern in GDM, particularly at ADORA2B (placenta) and ZFP57 (cord blood) promoters. The excessive intake of saturated fats was associated with GDM hypomethylation profiles and negatively correlated with ZFP57 methylation levels. This study highlights the influence of saturated fat intake on epigenetic changes in pregnancy, revealing potential biomarkers for GDM and emphasizing the need for tailored, population\u2010specific nutritional interventions to mitigate transgenerational health impacts.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70058","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T05:15:39Z","timestamp":1745471739000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats"],"prefix":"10.1002","volume":"69","author":[{"given":"Fatima","family":"Ahmad","sequence":"first","affiliation":[{"name":"College of Health and Life Sciences Hamad bin Khalifa University  Doha Qatar"},{"name":"Translational Medicine Department Sidra Medicine  Doha 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