{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:36:29Z","timestamp":1793900189205,"version":"4.8.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T00:00:00Z","timestamp":1744502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The EAT\u2010Lancet Commission recommends a sustainable, health\u2010focused diet, but its impact on inflammatory bowel disease (IBD) and metabolic mechanisms remains unclear. This study explores the association between the EAT\u2010Lancet diet and IBD risk. We included 187\u00a0558 participants from the UK Biobank, free from IBD at baseline. Dietary intake was assessed using a validated 24\u2010h dietary recall, and an EAT\u2010Lancet diet score was calculated. Incident IBD cases were identified through primary care, hospital data, and death registries. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Over a mean follow\u2010up of 13.15\u00a0years, 571 cases of Crohn's disease (CD) and 1066 of ulcerative colitis (UC) were recorded. HRs per 1\u2010point increase in the EAT\u2010Lancet score were 0.95 (95% CI: 0.91\u20130.98) for IBD, 0.95 (95% CI: 0.91\u20131.00) for UC, and 0.93 (95% CI: 0.87\u20130.98) for CD. Seven metabolites were identified as mediators, accounting for 10.7% of the association. Greater adherence to the EAT\u2010Lancet diet was associated with a trend toward reduced IBD risk, with identified metabolites mediating this association. These findings emphasize the nutritional relevance of the EAT\u2010Lancet diet in reducing IBD risk.<\/jats:p>","DOI":"10.1002\/mnfr.70059","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T02:22:26Z","timestamp":1744597346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma Metabolite Profiles Linked to EAT\u2010Lancet Diet and Risk of Inflammatory Bowel Disease: A Prospective Cohort Study From UK Biobank"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8358-4093","authenticated-orcid":false,"given":"Xiaohua","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"Department of Gastroenterology Affiliated Jinhua Hospital Zhejiang University School of Medicine  Jinhua Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmin","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00360-x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30333-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izab300"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-018-0022-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030579"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31788-4"},{"key":"e_1_2_9_8_1","first-page":"1","article-title":"Association of Adherence to the EAT\u2010Lancet Diet With Risk of Dementia According to Social Economic Status: A Prospective Cohort in UK Biobank","author":"Zhao W.","year":"2024","journal-title":"GeroScience"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31236-X"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155401"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oneear.2023.11.002"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2024.06.020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179139"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1275699"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60404-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515004821"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2017.66"},{"key":"e_1_2_9_19_1","first-page":"1","article-title":"Association of Healthy Lifestyle Behaviours With Incident Inflammatory Bowel Disease: A Population\u2010Based Prospective Cohort Study","author":"Ho F. 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