{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:25:50Z","timestamp":1787163950375,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The objective of the study was to evaluate the efficacy of\n                      <jats:italic>S. clausii<\/jats:italic>\n                      spores (SF174) in counteracting the deleterious effects of dietary fructose. Thirty\u2010days old male Wistar rats were treated for 6 weeks: control group: 0.5\u00a0mL of 10% sucrose solution (without probiotics); fructose group: 0.5\u00a0mL of 10% sucrose solution + high\u2010fructose diet (without probiotics); SF174 group: 0.5\u00a0mL of 10% sucrose solution containing SF174 (5 \u00d7 10\u2079 CFU) + high\u2010fructose diet. Fructose intake induced an increase in proinflammatory cytokines in portal plasma, liver, and skeletal muscle, a decrease in insulin sensitivity in both tissues and a condition of hepatic steatosis. An increase in the mitochondrial activity in the liver and a decrease in skeletal muscle were evidenced, together with an increase in the thiobarbituric acid reactive substances (TBARS) levels and a decrease in the antioxidant enzyme activity. All the above alterations were counteracted by probiotic administration. We here demonstrate for the first time that\n                      <jats:italic>S. clausii<\/jats:italic>\n                      SF174 counteracts low\u2010grade inflammation and insulin resistance induced by fructose, protects mitochondria from changes in oxidative capacity, and maintains unaltered the oxidative balance. Therefore,\n                      <jats:italic>S. clausii<\/jats:italic>\n                      SF174 administration can be an effective strategy to prevent the unhealthy consequences of dietary fructose.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.70063","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T06:47:55Z","timestamp":1744267675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fructose\u2010Induced Impairment of Liver and Skeletal Muscle Metabolism Is Prevented by Administration of\n                    <i>Shouchella clausii<\/i>\n                    Spores by Preserving Mitochondrial Function and Insulin Sensitivity"],"prefix":"10.1002","volume":"69","author":[{"given":"Angela","family":"Di Porzio","sequence":"first","affiliation":[{"name":"Department of Biology University of Naples Federico II  Naples 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