{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:28:49Z","timestamp":1790270929171,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T00:00:00Z","timestamp":1746316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SPG\/2021\/002487"],"award-info":[{"award-number":["SPG\/2021\/002487"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>The human gut microbiota regulates various aspects of Alzheimer's disease (AD) pathophysiology, influencing neuroinflammation and metabolic homeostasis. Dietary polyphenols, specifically phlorotannins from brown macroalgae, are known to mitigate AD's pathological effects due to their ability to pass through the blood\u2013brain barrier. Marine polyphenols extracted from <jats:italic>Sargassum wightii<\/jats:italic> were processed through simulated gastrointestinal digestion and in vitro fermentation. Characterization was performed using ultraviolet (UV), Fourier transform infrared spectroscopy (FTIR), HPLC, and liquid chromatography\u2010mass spectrometry\/mass spectrometry (LC\u2010MS\/MS) both before and after biotransformation. We evaluated their metal chelation capacity (Cu<jats:sup>2<\/jats:sup>\u207a and Fe<jats:sup>2<\/jats:sup>\u207a) and acetylcholinesterase (AChE) inhibitory activity using colorimetric assays. Additionally, the antioxidant capacity of the polyphenol extract was evaluated before and upon fermentation using 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl (DPPH), 2,2\u2032\u2010azinobis\u20103\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid (ABTS), and ferric reducing antioxidant potential (FRAP) assays. The extraction yield of polyphenols from <jats:italic>S. wightii<\/jats:italic> was 2.67 \u00b1 0.27\u00a0mg PGE\/g of macroalgae. In vitro biotransformation of these polyphenols resulted in the formation of various low\u2010molecular weight (LMW) compounds with enhanced metal chelation and AChE inhibition activities. Additionally, a substantial rise in antioxidant activity was observed postbiotransformation. <jats:italic>S. wightii<\/jats:italic> polyphenols become more effective after biotransformation, with enhanced bioactive properties and promising for use in diets to prevent and manage AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.70071","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T02:30:10Z","timestamp":1746412210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Simulated Digestion and Fermentation of Polyphenols From <i>Sargassum wightii<\/i> Acts as Potential Modulator of Alzheimer's Disease"],"prefix":"10.1002","volume":"69","author":[{"given":"Anushree","family":"Gade","sequence":"first","affiliation":[{"name":"Somaiya Institute for Research and Consultancy Somaiya Vidyavihar University, Vidyavihar (East)  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5097-3271","authenticated-orcid":false,"given":"Maushmi S.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Somaiya Institute for Research and Consultancy Somaiya Vidyavihar University, Vidyavihar (East)  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,4]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u201cDementia \u201d Accessed. 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