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Rats were divided into five groups receiving either a standard diet or a high\u2010fat high\u2010fructose (HFHF) diet supplemented or not with pterostilbene (15 or 30\u00a0mg\/kg body weight\/day; PT15 or PT30 groups, respectively) or resveratrol (30\u00a0mg\/kg body weight\/day; RSV30 group). Supplementation with the stilbenes reduced the hepatic steatosis induced by the HFHF diet. After the metabolomics study, 27 differentially expressed metabolites showed variable importance in projection scores &gt;\u00a01 and could be considered as potential biomarkers. Therefore, based on the pathway enrichment analysis, \u201criboflavin metabolism\u201d and \u201cnicotinate and nicotinamide metabolism\u201d revealed significant enrichment. Further, riboflavin showed positive correlations to\n                    <jats:italic>Eubacterium<\/jats:italic>\n                    and\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    , and negative correlations to\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Oscillospira<\/jats:italic>\n                    genera. Nicotinamide mononucleotide was only positively correlated to the\n                    <jats:italic>Ralstonia<\/jats:italic>\n                    genus. The untargeted metabolomics approach showed that the actions of resveratrol or pterostilbene on the prevention of liver steatosis are mediated by specific mechanisms of action. Particularly, pterostilbene, but not resveratrol, is suggested to significantly enrich riboflavin or nicotinate and nicotinamide metabolic pathways.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70078","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T21:11:18Z","timestamp":1746047478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2709-4118","authenticated-orcid":false,"given":"Alfredo","family":"Fern\u00e1ndez\u2010Quintela","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Nutrition and Obesity Group Department of Nutrition and Food Science University of the Basque Country (UPV\/EHU), Lucio Lascaray Research Centre  Vitoria\u2010Gasteiz Spain"},{"name":"BIOARABA Institute of Health  Vitoria\u2010Gasteiz Spain"},{"name":"CIBERobn Physiopathology of Obesity and Nutrition Institute of Health Carlos III (ISCIII)  Vitoria\u2010Gasteiz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily P.","family":"Laveriano\u2010Santos","sequence":"additional","affiliation":[{"name":"Global Health Institute (ISGlobal)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Portol\u00e9s","sequence":"additional","affiliation":[{"name":"Enviromental and Public Health Analytical Chemistry Research Institute for Pesticides and Water (IUPA) Universitat Jaume I  Castell\u00f3n de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Gual\u2010Grau","sequence":"additional","affiliation":[{"name":"Nutrigenomics and Research Group Department of Biochemistry and Biotechnology Universitat Rovira i Virgili  Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Vicente","family":"Sancho","sequence":"additional","affiliation":[{"name":"Enviromental and Public Health Analytical Chemistry Research Institute for Pesticides and Water (IUPA) Universitat Jaume I  Castell\u00f3n de la Plana Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria P.","family":"Portillo","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Nutrition and Obesity Group Department of Nutrition and Food Science University of the Basque Country (UPV\/EHU), Lucio Lascaray Research Centre  Vitoria\u2010Gasteiz Spain"},{"name":"BIOARABA Institute of Health  Vitoria\u2010Gasteiz Spain"},{"name":"CIBERobn Physiopathology of Obesity and Nutrition Institute of Health Carlos III (ISCIII)  Vitoria\u2010Gasteiz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"111","article-title":"The Importance of Energy Balance","volume":"9","author":"Hill J. 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