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Tibetan tea is a potential dietary intervention for inflammation, it's effect on SD\u2010induced intestinal inflammation remains unclear. This study investigates the alleviating effects of Tibetan tea water\u2010soluble extract (TTE) on intestinal dysfunction in SD mice. After TTE supplementation, the physiological activity, inflammatory cytokines, and oxidative stress levels were assessed in SD\u2010induced intestinal dysfunction mice. SD increased ROS levels and pro\u2010inflammatory cytokines in plasma and small intestine, causing intestinal injury characterized by reduced goblet cells, decreased Mucin2 (MUC2) expression, and impaired tight junction proteins. Conversely, TTE reversed these disorders and improved mucosal injury in the small intestine. Furthermore, TTE modulated gut microbiota by enriching probiotics linked to SCFA production and restored SD\u2010induced metabolic disturbances in the small intestine and systemic circulation, particularly affecting tricarboxylic acid (TCA) cycle, urea cycle, and TAG\u2010related metabolites. Overall, TTE remarkably ameliorated SD\u2010induced intestinal dysfunction through reducing ROS, restoring intestinal barrier function, and regulating the gut microbiome, which suggested that Tibetan tea could contribute to the treatment of intestinal inflammation.<\/jats:p>","DOI":"10.1002\/mnfr.70098","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T06:59:41Z","timestamp":1747033181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tibetan Tea Alleviates the Intestinal Dysfunction in Sleep\u2010Deprived Mice Through Regulating Oxidative Stress and Inflammation\u2010Related Intestinal Metabolisms"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-3741","authenticated-orcid":false,"given":"Ge","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Metabolomics and Proteomics Technology Platform West 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