{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:58:19Z","timestamp":1790726299957,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Adipocyte hypertrophy, driven by lipid accumulation, is crucial in the development of obesity. Wild blueberry (WB;\n                    <jats:italic>Vaccinium angustifolium<\/jats:italic>\n                    ) (poly)phenols (PPs) metabolites may modulate adipogenesis and the development of obesity. This study examines WB PP metabolites\u2019 effects on lipid accumulation, lipid metabolism, and oxidative stress in mature 3T3\u2010L1 adipocytes. Differentiated 3T3\u2010L1 adipocytes were treated for 48 h with free fatty acids (FFAs; oleic\/palmitic acid 750\u00a0\u00b5M, 2:1 ratio) and WB\u2010derived PPs, including ferulic acid (FA), isoferulic acid (IA), vanillic acid (VA), and syringic acid (SA) at physiological and supra\u2010physiological concentrations. Assessments included lipid accumulation, glycerol release, and markers of lipid metabolism (sterol regulatory element\u2010binding protein 1c [SREBP\u20101], fatty acid synthase [FASN], FAB4) and oxidative stress (DNA damage, 8\u2010hydroxy 2\u2010deoxyguanosine [8OHdG], nuclear erythroid factor 2\u2010related factors 2 (NRF2), heme oxygenase 1 [HO\u20101]). FFAs significantly increased lipid accumulation, glycerol release, and FASN levels, while reducing HO\u20101 levels, without affecting other markers. WB PP metabolites did not reduce lipid accumulation, but IA and VA reduced FASN levels (\u221225% and \u221226%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05), and SA improved HO\u20101 levels (+150%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05). Despite the different effects observed, the findings obtained under our experimental conditions seem to suggest that IA, VA, and SA may modulate lipid metabolism and oxidative stress markers. However, further studies are fundamental to corroborate the findings obtained and support the contribution of these BB PPs metabolites and other compounds in the prevention and management of obesity.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.70101","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T06:13:43Z","timestamp":1746771223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Differential Effects of Wild Blueberry (Poly)Phenol Metabolites in Modulating Lipid Metabolism and Oxidative Stress in 3T3\u2010L1 Adipocytes"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-1863","authenticated-orcid":false,"given":"Samuele","family":"Venturi","sequence":"first","affiliation":[{"name":"Division of Human Nutrition Department of Food Environmental and Nutritional Sciences (DeFENS) Universit\u00e0 degli Studi di Milano  Milan 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