{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:52:58Z","timestamp":1767707578434,"version":"3.41.2"},"reference-count":56,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32161143021 81271410"],"award-info":[{"award-number":["32161143021 81271410"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Parkinson's disease (PD) is the second largest neurodegenerative disease after Alzheimer's disease (AD), and neuroinflammation is one of its important causes. So far, there is no clear evidence that drugs can improve the onset of PD, so it is crucial to find and develop effective drugs for PD treatment. Abscisic acid (ABA) is a phytohormone with structural and medicinal functions similar to the PPAR\u2010\u03b3 agonist thiazolidinedione drugs (TZDs). It has played therapeutic effects in a variety of inflammatory diseases, but the role and mechanism of PD have not been defined. The present study aimed to gain insight into the neuroprotection effects and mechanism of ABA in MPTP (1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine)\u2010induced PD models. In this study, we observed that in addition to significant behavioral abnormalities in MPTP\u2010induced mice, Inflammatory parameters such as ion calcium\u2010binding adaptor molecule 1 (IBA\u20101), glial fibrillary acid protein (GFAP), tumor necrosis factor (TNF\u2010\u03b1), interleukin\u20101\u03b2 (IL\u20101\u03b2), and interleukin\u20106 (IL\u20106) were also significantly increased in substantia nigra pars compacta (SNpc). ABA treatment restored behavioral abnormalities and significantly reduced these inflammatory parameters in MPTP\u2010induced mice. Interestingly, these effects were not related to the activation of the lanthionine synthetase C\u2010like protein 2 (LANCL2) but were related to the regulation of the peroxisome proliferator\u2010activated receptor gamma (PPAR\u2010\u03b3). Intraperitoneal injection of ABA ameliorated the MPTP\u2010induced increase in PPAR\u2010\u03b3 and peroxisome proliferator\u2010activated receptor co\u2010activator\u20101\u03b1 (PGC\u20101\u03b1) expression. Our findings suggest that intraperitoneal injection of ABA is neuroprotective against neurodegeneration induced by MPTP, and this effect is associated with the downregulation of neuroinflammation and modulation of the expression of PPAR\u2010\u03b3 and PGC\u20101\u03b1. These results suggest that ABA is expected to develop as a therapeutic candidate for PD.<\/jats:p>","DOI":"10.1002\/mnfr.70111","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:34:30Z","timestamp":1748334870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroprotective Effect of Abscisic Acid on MPTP\u2010Induced Parkinson's Disease in Mice"],"prefix":"10.1002","volume":"69","author":[{"given":"Zhengjia","family":"Yang","sequence":"first","affiliation":[{"name":"School of Life Sciences Henan University  Kaifeng P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences Henan University  Kaifeng P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangrui","family":"Kong","sequence":"additional","affiliation":[{"name":"School of Life Sciences Henan University  Kaifeng P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-3392","authenticated-orcid":false,"given":"Jianshe","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Life Sciences Henan University  Kaifeng P.R. 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