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We tested the efficacy of the 15%Amylose\/Soy\/FO diet in preventing colitis\u2010induced colorectal cancer using an azoxymethane\/dextran sodium sulfate BALB\/c mouse model. The 15%Amylose\/Soy\/FO diet significantly reduced colon tumor numbers compared to a Western diet and this was associated with a reduction in blood glucose, and a trend towards an increase in plasma \u03b2\u2010hydroxybutyrate and an increase in liver fatty acid synthase, suggesting a systemic metabolic shift from glucose to fatty acids as an energy source. In addition, our CHO diet reduced proinflammatory cytokines, induced a marked change in the fecal microbiome, an increase in cecal and fecal acetate, and a reduction in interleukin\u201017A expressing cells in the colonic tumors of mice on the 15%Amylose\/Soy\/FO diet. Taken together, our results suggest the 15%Amylose\/Soy\/FO diet ameliorates colitis and prevents the subsequent development of colorectal cancer, in part by an acetate\u2010mediated reduction in T<jats:sub>H<\/jats:sub>17 cell development.<\/jats:p>","DOI":"10.1002\/mnfr.70113","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T01:25:18Z","timestamp":1749518718000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low Carbohydrate Diet Containing Soy Protein and Fish Oil Reduces AOM\/DSS\u2010Induced Colon Cancer, in Part, by an Acetate\u2010Mediated Reduction in T<sub>H<\/sub>17 Cell Differentiation"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-6609","authenticated-orcid":false,"given":"Ingrid","family":"Elisia","sequence":"first","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Yeung","sequence":"additional","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kowalski","sequence":"additional","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Wong","sequence":"additional","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colton","family":"Dietrich","sequence":"additional","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vianne","family":"Chang","sequence":"additional","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Wu","sequence":"additional","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Hollman","sequence":"additional","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Dyer","sequence":"additional","affiliation":[{"name":"Analytical Core for Metabolomics and Nutrition BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoi Nguyen","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Microbiome Insights  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Krystal","sequence":"additional","affiliation":[{"name":"The Terry Fox Laboratory BC Cancer  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21772"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323926"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00534-x"},{"key":"e_1_2_10_5_1","first-page":"53","article-title":"Current Management of Inflammatory Bowel Disease and Colorectal Cancer","volume":"4","author":"Mattar M. 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