{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T16:33:41Z","timestamp":1754152421614,"version":"3.41.2"},"reference-count":49,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013514","name":"Wereld Kanker Onderzoek Fonds","doi-asserted-by":"publisher","award":["IIG_FULL_2021_023"],"award-info":[{"award-number":["IIG_FULL_2021_023"]}],"id":[{"id":"10.13039\/501100013514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000321","name":"World Cancer Research Fund","doi-asserted-by":"publisher","award":["IIG_FULL_2022_007"],"award-info":[{"award-number":["IIG_FULL_2022_007"]}],"id":[{"id":"10.13039\/501100000321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Patients with stage II\u2010III colorectal cancer (CRC) often receive fluoropyrimidine\u2010based chemotherapy, usually combined with other regimens, of which \u223c50% experience severe chemotherapy\u2010induced toxicities. The B\u2010vitamin folate has been associated with toxicity risk, possibly through effects on DNA methylation. Here, we examined the potential role of folate\u2010associated DNA methylation in the context of chemotherapy\u2010induced toxicities. Systematic literature searches were conducted to identify studies investigating either DNA methylation profiles associated with folate status\/intake or with toxicities. Overlapping CpG sites and genes across studies investigating associations for \u201cfolate\u2010DNA methylation\u201d and \u201cDNA methylation\u2010toxicities\u201d were identified. The probability of overlap was tested using hypergeometric tests and Gene Ontology and KEGG pathway analyses were performed. Six studies were included. A significant number of CpGs and genes overlapped with altered methylation in response to both folate and hand\u2010foot syndrome (HFS) or thrombocytopenia. Moreover, methylation of genes within the KEGG pathway \u201cfocal adhesion\u201d was related to folate status\/intake and occurrence of HFS, thrombocytopenia, and neutropenia. We identified some overlapping DNA methylation profiles related to both folate exposures and toxicities. This provides preliminary evidence implying folate\u2010associated DNA methylation may determine risk of toxicities, and therefore may be considered a modifiable factor for improving patient outcomes.<\/jats:p>","DOI":"10.1002\/mnfr.70127","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:25:15Z","timestamp":1748316315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Folate\u2010Associated DNA Methylation and Chemotherapy\u2010Induced Toxicities in Patients With Colorectal Cancer"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0619-9248","authenticated-orcid":false,"given":"Nienke R. 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