{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:46Z","timestamp":1772118826073,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Vitamin D deficiency, which has been a global health issue for decades, is involved in gut health and diseases. We examined the health benefits of\n                      <jats:italic>Grifola frondosa<\/jats:italic>\n                      (maitake mushroom), a potent dietary source of fungal vitamin D (D\n                      <jats:sub>2<\/jats:sub>\n                      ), on DSS\u2010induced colitis in vitamin D\u2010deficient mice. C57BL\/6J mice were fed a control diet, vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      \u2010deficient diet (DD), maitake\u2010fortified DD, or vitamin D\n                      <jats:sub>2<\/jats:sub>\n                      \u2010fortified DD for 6 weeks. LC\u2010MS\/MS analysis demonstrated that maitake\u2010fed mice showed an increased 25(OH)D\n                      <jats:sub>2<\/jats:sub>\n                      alternative to 25(OH)D\n                      <jats:sub>3<\/jats:sub>\n                      in plasma\n                      <jats:sub>,<\/jats:sub>\n                      as well as the mice fed an equivalent dose of vitamin D\n                      <jats:sub>2<\/jats:sub>\n                      . The mRNA expression profiles of vitamin D\u2010responsive genes, including renal\n                      <jats:italic>Cyp24a1<\/jats:italic>\n                      and\n                      <jats:italic>Cyp27b1<\/jats:italic>\n                      , were normalized in the maitake\u2010fed mice. Severe DSS\u2010induced colitis observed in DD mice was attenuated in maitake\u2010fed mice; the accumulation of immune cells in the colonic mucosa and protein expression of colonic claudin\u20102, a target gene of the vitamin D receptor, were comparable to that in control mice. Dietary intake of maitake was effective in improving vitamin D status and biological function, demonstrating a potential attenuative effect on severe DSS\u2010induced colitis in vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      deficient mice, as well as equivalent doses of vitamin D\n                      <jats:sub>2<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.70135","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T02:09:00Z","timestamp":1749780540000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuative Effect of\n                    <i>Grifola frondosa<\/i>\n                    (Maitake Mushroom) on Severe DSS\u2010Induced Colitis in Vitamin D\u2010Deficient Mice"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-1247","authenticated-orcid":false,"given":"Miyu","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Department of Biotechnology Faculty of Engineering Toyama Prefectural University Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Engineering Toyama Prefectural University Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kugimiya","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Engineering Toyama Prefectural University Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seita","family":"Chudan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Engineering Toyama Prefectural University Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-6965","authenticated-orcid":false,"given":"Yukihiro","family":"Furusawa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering Faculty of Engineering Toyama Prefectural University Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Ikushiro","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Engineering Toyama Prefectural University Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3318"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.4.694"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2013.213"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.117.015578"},{"key":"e_1_2_10_6_1","article-title":"Vitamin D: Marker, Measurand & Measurement","author":"Dirks N. 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