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In a double\u2010blind, randomized, placebo\u2010controlled study, participants consumed daily doses of Probio87 (1 \u00d7 10<jats:sup>9<\/jats:sup> CFU\/sachet) or a placebo for 12 weeks. Vaginal swabs were collected, and DNA was extracted for 16S rRNA and the internal transcribed spacer (ITS) region amplification via PCR, followed by sequencing of bacterial and fungal microbiota. The probiotic group showed improved alpha and beta diversity, with an increase in beneficial <jats:italic>Lactobacillus<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.014) and <jats:italic>Phascolarctobacterium faecium<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.041), while decreasing the abundance of pathogens like <jats:italic>Streptococcus<\/jats:italic> and <jats:italic>Candida<\/jats:italic> (<jats:italic>p<\/jats:italic> = 0.011). Additionally, vaginal health questionnaires linked probiotic use to improved vaginal and mental health in HPV\u2010positive women. <jats:italic>L. plantarum<\/jats:italic> Probio87 demonstrated clinical and psychological benefits in HPV\u2010positive women by balancing the vaginal microbiome, reducing pathogenic species, and promoting the growth of beneficial microorganisms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.70142","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:05:17Z","timestamp":1749614717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of the Probiotic on the Modulation of Vaginal Bacterial and Fungal Microbiota in HPV\u2010Positive Women"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0841-6152","authenticated-orcid":false,"given":"Pei","family":"Xu","sequence":"first","affiliation":[{"name":"College of Culinary and Food Science Engineering Sichuan Tourism University  Chengdu China"},{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mageswaran","family":"Uma Mageswary","sequence":"additional","affiliation":[{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azka Ainun","family":"Nisaa","sequence":"additional","affiliation":[{"name":"School of Industrial Technology Universiti Sains Malaysia  Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shandra Devi","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Faculty of Medicine AIMIST University  Bedong Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Binti","family":"Samsudin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; 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