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This study evaluated the associations between PBD and IBD risk and explored potential mediators. This prospective cohort study included 143\u00a0434 UK Biobank participants, using 24\u2010h dietary recalls to calculate PBD indexes. Cox regression assessed associations between PBD and IBD risk. Decomposition and mediation analyses evaluated dietary components and serum biomarkers. During a mean follow\u2010up of 14.5 years, 1117 participants developed IBD (795 UC, 322 CD). Results showed inverse associations between hPDI and UC risk (0.92, 95% CI = 0.86\u20130.99) and CD risk (0.86, 95% CI = 0.77\u20130.96), and between PDI and CD risk (0.86, 95% CI = 0.77\u20130.96). A positive association was found between uPDI and CD risk (1.15, 95% CI = 1.02\u20131.29). Fruits and vegetables were identified as protective factors. Neutrophils, white blood cells, and CRP were major mediators of the associations between PBD and IBD risk. The healthy plant\u2010based diet is inversely associated with IBD risk and may be partly explained by the anti\u2010inflammatory properties of plant\u2010based foods.<\/jats:p>","DOI":"10.1002\/mnfr.70151","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T12:01:24Z","timestamp":1752062484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Healthy Plant\u2010Based Diet Is Associated With a Reduced Risk of Inflammatory Bowel Disease: A Large\u2010Scale Prospective Analysis"],"prefix":"10.1002","volume":"69","author":[{"given":"Zhenhe","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology 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