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Here, we report that changes in the gut microbiome of offspring after maternal exposure to 50% food restriction and 45% high\u2010fat diet during pregnancy can affect the risk of metabolic dysfunction\u2010associated steatotic liver disease (MASLD) in offspring in a sex\u2010specific manner. Notably, despite no significant difference in body weight, plasma triglyceride and leptin levels were significantly increased in male offspring compared with the controls. The relative abundance of the butyrate\u2010producing genera of the <jats:italic>Lachnospiraceae<\/jats:italic> family was dependent on the sex of the offspring and correlated with plasma triglyceride and leptin levels. Interestingly, male offspring in the 50% restricted diet or 45% high\u2010fat diet groups had reduced butyrate levels compared with the control group and were affected by oxidative damage and hepatic lipogenesis. Our findings suggest that the maternal diet during pregnancy affects the gut microbiota of male offspring in a sex\u2010specific manner, potentially predisposing them to MASLD later in life through dysregulation of lipid metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.70153","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T02:11:12Z","timestamp":1751508672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Altered Abundance of Butyrate\u2010Producing <i>Lachnospiraceae<\/i> by Maternal Diet During Pregnancy Potentially Influences MASLD\u2010Related Lipid Dysregulation in Male Rat Offspring"],"prefix":"10.1002","volume":"69","author":[{"given":"Soo\u2010Min","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology College of Medicine Ewha Medical Research Institute Ewha Womans University Mokdong Hospital  Seoul Republic of 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