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Although many biomarkers of food intake (BFIs) have been validated, we aimed to explore how food\u2010BFI relationships are affected by genetic and lifestyle factors among Caribbean Hispanic adults. Dietary, clinical, anthropometric, blood metabolomics, and genotype data from 782 Puerto Rican adults were available. Thirty\u2010one BFI\u2010food intake relationships were assessed using linear regression, including covariates based on significant covariate\u2010BFI associations (i.e., age, body weight, physical activity, and sex). We observed 12 known BFI\u2010food pairs that reached statistical significance, of which 11 remained significant after adjustment. Applying genome\u2010wide association tests of blood metabolites to BFI\u2010food pairs, genetic variants rs7078243 and rs62501664 were identified as modifying relationships with 3\u2010methylxanthine\u2010coffee and 3\u2010methylhistidine\u2010poultry, respectively. 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