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This study investigated the anti\u2010<jats:italic>Helicobacter<\/jats:italic> and anti\u2010inflammatory effects of <jats:italic>Curcuma longa<\/jats:italic> extract (CLE) as a potential treatment for <jats:italic>H. pylori<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Ultra\u2010high performance liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\u2010Q\u2010TOF\/MS) analysis identified 18 chemical compounds in CLE, with curcumin, bisdemethoxycurcumin, and bisacurone as major active components. In vitro experiments demonstrated that CLE completely inhibited the growth of <jats:italic>H. pylori<\/jats:italic> Sydney strain 1 (SS1) in a dose\u2010dependent manner and exhibited synergistic effects when combined with amoxicillin. In a mouse model infected with <jats:italic>H. pylori<\/jats:italic> SS1 showed that oral administration of CLE for 4 weeks effectively eradicated <jats:italic>H. pylori<\/jats:italic> from the stomach without causing toxicity, as evidenced by the CLO test and reduced levels of <jats:italic>H. pylori<\/jats:italic>\u2010associated genes. Furthermore, CLE attenuated inflammatory cell infiltration in the gastric mucosa of infected mice and significantly reduced the expression of proinflammatory cytokines and matrix metalloproteinases in <jats:italic>H. pylori<\/jats:italic>\u2010infected AGS cells, a human gastric cancer cell line.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>These findings suggest that CLE is a promising candidate for the treatment of <jats:italic>H. pylori<\/jats:italic> infection, exhibiting potent antibacterial and anti\u2010inflammatory properties.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.70161","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T02:04:16Z","timestamp":1751249056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010Inflammatory and Antibacterial Properties of <i>Curcuma longa<\/i> Extract Against <i>Helicobacter pylori<\/i>"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-0104","authenticated-orcid":false,"given":"Jeongsook","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Physiology College of Veterinary Medicine Chungnam National University Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwan\u2010Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research National Institute of Horticultural Herbal Science Rural Development Administration Eumseong Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Kyu","family":"Jang","sequence":"additional","affiliation":[{"name":"BK21 FOUR KNU Creative BioResearch Group School of Life Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research National Institute of Horticultural Herbal Science Rural Development Administration Eumseong Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akila","family":"Cooray","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Veterinary Medicine Chungnam National University Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Seob","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Herbal Crop Research National Institute of Horticultural Herbal Science Rural Development Administration Eumseong Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7192-4791","authenticated-orcid":false,"given":"Kyu Pil","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Veterinary Medicine Chungnam National University Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Young","family":"Lee","sequence":"additional","affiliation":[{"name":"BK21 FOUR KNU Creative BioResearch Group School of Life Sciences Kyungpook National University Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.06.004"},{"key":"e_1_2_10_4_1","first-page":"1","volume-title":"\u201cSchistosomes, Liver Flukes and Helicobacter Pylori\u201d","year":"1994"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409105357"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i41.6518"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.03.039"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj264"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2022.1990041"},{"key":"e_1_2_10_10_1","first-page":"35","article-title":"Comparison of 7\u2010and 14\u2010Day Eradication Therapy for Helicobacter pylori With First\u2010and Second\u2010Line Regimen: Randomized Clinical Trial","volume":"35","author":"Kim T. 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