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This study aimed to investigate the impact of HS on testicular NAD<jats:sup>+<\/jats:sup> metabolism and assess the potential of NAD<jats:sup>+<\/jats:sup> precursor supplementation in alleviating heat stress (HS)\u2010induced reductions in semen quality. This study aimed to investigate the impact of HS on testicular NAD<jats:sup>+<\/jats:sup> metabolism and assess the potential of NAD<jats:sup>+<\/jats:sup> precursor supplementation in alleviating HS\u2010induced reductions in semen quality. In this study, 24 Rongchang boars were randomly divided into three groups: a control group (CON), HS group, and HS supplementation with nicotinamide riboside group (HS\u2010NR). After the initial feeding phase, the boars were exposed to either a thermoneutral or HS environment for 2 weeks. In this study, we identified NAD<jats:sup>+<\/jats:sup> deficiency as a hallmark of testicular damage under HS. Supplementation with NR effectively restored testicular NAD<jats:sup>+<\/jats:sup> metabolism. NR supplementation also improved semen quality, reduced spermatogenesis defects, and attenuated oxidative stress and inflammation induced by HS. These findings highlight the potential of NAD<jats:sup>+<\/jats:sup> precursors as a promising nutritional strategy to mitigate the adverse effects of HS on male reproductive health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.70162","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T02:30:37Z","timestamp":1751250637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nicotinamide Riboside Supplementation Alleviates Heat Stress\u2010Induced Testicular Damage and Improves Semen Quality in Boars"],"prefix":"10.1002","volume":"69","author":[{"given":"Wenxue","family":"Shen","sequence":"first","affiliation":[{"name":"Animal Nutrition Institute Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory for Animal Disease\u2010Resistant Nutrition of the Ministry of Education of China Sichuan Agricultural University  Chengdu China"},{"name":"Key Laboratory of Animal 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